[1]包乐媛,张业尼,钱磊,等.大豆肽对高脂血症大鼠的降脂作用[J].大豆科学,2007,26(05):752-756.[doi:10.3969/j.issn.1000-9841.2007.05.024]
　BAO Le-uan,ZHANG Ye-i,QIAN Lei,et al.EFFECTS OF SOYBEAN PEPTIDES ON BLOOD LIPIDS IN HYPERLIPIDEMIA RATS[J].Soybean Science,2007,26(05):752-756.[doi:10.3969/j.issn.1000-9841.2007.05.024]
点击复制

大豆肽对高脂血症大鼠的降脂作用

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第26卷 期数: 2007年05期 页码: 752-756 栏目: 出版日期: 2007-10-25
Title:
EFFECTS OF SOYBEAN PEPTIDES ON BLOOD LIPIDS IN HYPERLIPIDEMIA RATS
文章编号:
1000-9841(2007)05-0752-05
作者:
包乐媛; 张业尼; 钱磊; 王建玲; 邹菁; 路福平; 杜连祥
天津市工业微生物重点实验室，天津科技大学生物工程学院，天津 300457
Author(s):
BAO Le-uan; ZHANG Ye-i; QIAN Lei; WANG Jian-ing; ZOU Jing; LU Fu-ing; DU Lian-iang
Tianjin Key Lab of Industrial Microbiology，College of Biotechnology，Tianjin University of Science & Technology，Tianjin 300457
关键词:
大豆肽; 血脂; 抗氧化; 血液流变学
Keywords:
Soybean peptides ; Lipid ; Antioxidation ; Lipid hemorheolgy
分类号:
R962
DOI:
10.3969/j.issn.1000-9841.2007.05.024
文献标志码:
A
摘要:
研究大豆肽对高脂血症大鼠的降血脂、抗氧化作用以及对血液流变学指标的影响。采用高脂饲料喂养 SD 大鼠造成高脂血症模型，然后随机分组：正常组、高脂模型组、血脂康组( 100 mg kg-1d-1 )、大豆肽灌胃组( 400 mg kg-1d-1)、大豆肽灌胃组( 800 mg kg-1d-1 )、大豆肽腹腔注射组( 100 mg kg-1d-1)、大豆肽腹腔注射组( 400 mg kg-1d-1)，正常组给予普通饲料喂养，其余组给予高脂饲料。持续给药大豆肽 30 d ，期间每两周眼静脉取血一次，分离血清，检测TC、TG 和HDL- 指标；实验结束当天腹主动脉取血，分离血清，检测SOD、MDA 和NO 指标。结果显示大豆肽能显著降低高脂血症大鼠的TC、TG 和 LDL-，但对HDL- 没有显著影响；大豆肽给药组的SOD 指标明显高于模型对照组，而MDA 和 NO 指标则显著降低。表明大豆肽液对高脂血症大鼠具有一定的降脂作用，能降低血浆黏度，同时提高机体抗氧化能力。
Abstract:
To observe the effects of soybean peptides on regulation of liquid metabolism，hemorheological indexes，antioxidation in rats with hyperlipidemia.Sixty-three SD rats were randomly divided into seven groups as normal control group，model control group，Xuezhikang (100 mg kg-1d-1，i.p.) group，soybean peptide (400 mg kg-1d-1 ，i.g.) group，soybean peptide (800 mg kg-1d-1 ，i.g.) group，soybean peptide (100 mg kg-1d-1，i.p.) group and soybean peptide (400 mg kg-1d-1 ，i.p.) group.All rats were fed with high-lipid forage except normal control group.Soybean peptides were administered continually for 30 days and blood was collected to detect TC、TG and HDL.C in serum once every two weeks and the levels of serum SOD、MDA and NO were assayed at the last day.Results showed that soybean peptides could significantly decrease TC、TG and LDL-C levels in experimental hyperlipidemia rats (P<0.05)，but it had no significant effect on the level of HDL.C (P>0.05)The activity of SOD in rats of soybean peptides administered groups were much higher than those of model control group (P<0.05).Meanwhile，the MDA and NO levels in rats of soybean peptides administered groups were much lower than those of model control group (P<0.05).The results suggested that the Soybean Peptides can regulate the liquid metabolism，improve hemorheological indexes，increase the activity of scavenging free radicals in rats with hyperlipidemia.

参考文献/References:

［1］李佃淳，张红，李玉中，等．复方芪参降脂饮抗实验性动脉粥样硬化作用及其可能机制[J].中国临床药学杂志，2006，15(3)：156-159．

[2]李宝华，郑广娟，张文高，等．软脉降脂胶囊对实验性高脂血症大鼠血脂及MDA、SOD、NO的影响[J]．中西医结合心脑血管病杂志，2004，2(4)：220-222．
[3]沃兴得，崔小强，唐利华．姜黄素对食耳性高脂血症大鼠血浆蛋白代谢相关酶活性的影响[J]．中国动脉硬化杂志，2003，11(3)：223-226．
[4]高春霞．大豆多肽生理活性、应用与前景分析[J]．大豆通报，2006，19(4)：18-22．
[5]江和源，吕飞杰，邰建祥．大豆中生物活性成分及其功能[J]．大豆科学，2000，19(2)：160-164．
[6]赵秀娟，王小雪，吴博学，等．大豆活性肽粉对喂饲高脂饲料大鼠血脂的影响[J]．中国卫生检验杂志，2002，12(4)：421-422．
[7]汪庆辉，崔东善，林杨，等．大豆蛋白肽加工工艺技术概述[J]．大豆通报，2001，19(4)：18-19．
[8]钱磊，包乐媛，鄂旭，等．脱脂豆粕酶法制备大豆肽[J]．化学与生物工程，2007，24(3)：39-43．
[9]赵秀娟，贾莉，赵云财．大豆活性肽对大鼠体内高胆固醇代谢的影响[J]．中国公共卫生，2004，20(9):1094-1096．
[10]刘忆梅，陈朝晖．大豆蛋白肽降血脂功能性的研究[J]．大豆通报，2004，19(3):22．
[11]任世存，任延明，乔晓鸣．沙棘降脂胶囊对高脂血症大鼠脂代谢及血液流变学影响的研究[J]．江苏中医药，2005，26(8)：52-53．
[12]朱艳媚，多杰，陈秋红．金诃降脂胶囊对高脂血症大鼠血脂和血液流变学的影响[J]．青海医学院学报，2004，25(2)：101-103．
[13]成龙，梁日欣，杨滨，等．红花提取物对高脂血症大鼠降脂和抗氧化的实验研究[J]．中国实验方剂学杂志，2006，12(9)：25-27．
[14]朱慧娟，赵岩，李世芬，等．大豆提取物抗氧化作用研究[J]．江苏卫生保健，2007，9(1)：5-6．

相似文献/References:

[1]刘 政,胡丽菊,赵丽薇,等.超声波辅助分步酶解法制备大豆肽的研究[J].大豆科学,2013,32(03):402.[doi:10.11861/j.issn.1000-9841.2013.03.0402]
　LIU Zheng,HU Li-ju,ZHAO Li-wei,et al.Step-by-step Enzymatic Hydrolysis Preparation of Soybean Peptide with Ultrasonic-Assisted Method[J].Soybean Science,2013,32(05):402.[doi:10.11861/j.issn.1000-9841.2013.03.0402]
[2]张彬,刘贺,徐婧婷,等.大豆蛋白酶解物的抗消化性及离子强度对其聚集的影响[J].大豆科学,2011,30(04):632.[doi:10.11861/j.issn.1000-9841.2011.04.0632]
　ZHANG Bin,LIU He,XU Jing-ting,et al.Anti-digestion and Ionic Strength Effect to Aggregation of Soy Protein Hydrolysates[J].Soybean Science,2011,30(05):632.[doi:10.11861/j.issn.1000-9841.2011.04.0632]
[3]李丹,刘春雷,刘昊飞,等.响应面优化豆粕生物肽的生产工艺研究[J].大豆科学,2011,30(05):851.[doi:10.11861/j.issn.1000-9841.2011.05.0851]
　LI Dan,LIU Chun-lei,LIU Hao-Fei,et al.Response Surface Optimization of Soybean Production Technology of Bio-peptide[J].Soybean Science,2011,30(05):851.[doi:10.11861/j.issn.1000-9841.2011.05.0851]
[4]钱森和,厉荣玉,魏 明,等.二元复合菌固态发酵豆粕制备大豆肽的研究[J].大豆科学,2011,30(01):131.[doi:10.11861/j.issn.1000-9841.2011.01.0131]
　QIAN Sen-he,LI Rong-yu,WEI Ming,et al.Preparation of Soybean Peptide from Soybean Meal by Solid-Stated Fermented with Binary Compound Strains[J].Soybean Science,2011,30(05):131.[doi:10.11861/j.issn.1000-9841.2011.01.0131]
[5]王若敏,陈杰,徐婧婷,等.pH值和热处理对大豆肽稳定性的影响[J].大豆科学,2009,28(06):1058.[doi:10.11861/j.issn.1000-9841.2009.06.1058]
　WANG Ruo-min,CHEN Jie,XU Jing-ting,et al.Effect of pH and Heat Treatment on Stability of Soybean Peptides[J].Soybean Science,2009,28(05):1058.[doi:10.11861/j.issn.1000-9841.2009.06.1058]
[6]陈敏,蔡会武,邵纪生,等.双酶解法提取大豆蛋白的工艺研究[J].大豆科学,2010,29(03):537.[doi:10.11861/j.issn.1000-9841.2010.03.0537]
　CHEN Min,CAI Hui-wu,SHAO Ji-sheng,et al.Extraction of Soybean Protein by Dual-Enzyme hydrolysis Method[J].Soybean Science,2010,29(05):537.[doi:10.11861/j.issn.1000-9841.2010.03.0537]
[7]李俏俏,王清路,薛金艳.大豆异黄酮对绝经女性血清中脂类物质的影响[J].大豆科学,2009,28(01):172.[doi:10.11861/j.issn.1000-9841.2009.01.0172]
　LI Qiao-qiao,WANG Qing-lu,XUE Jin-yan.Effect of Soy Isoflavone on the Serum Lipid Level of Postmenopausal Women[J].Soybean Science,2009,28(05):172.[doi:10.11861/j.issn.1000-9841.2009.01.0172]
[8]陈济琛,李善仁,蔡海松,等.大豆肽的制备及其在养殖业中的应用[J].大豆科学,2009,28(02):341.[doi:10.11861/j.issn.1000-9841.2009.02.0341]
　CHEN Ji-chen,LI Shan-ren,CAI Hai-song,et al.Preparation of Soybean Peptides and Its Applications in Breeding Industry[J].Soybean Science,2009,28(05):341.[doi:10.11861/j.issn.1000-9841.2009.02.0341]

备注/Memo

基金项目：天津科技大学自然科学资金资助(20060206)

作者简介：包乐媛（1979-），女，助教，研究方向为生物活性肽。E-mail: baoleyuan@tust.edu.cn

更新日期/Last Update: 2014-10-20