[1]杨茂区??陈 伟 冯 　 磊.大豆异黄酮的生理功能研究进展*[J].大豆科学,2006,25(03):320-324.[doi:10.11861/j.issn.1000-9841.2006.03.0320]
　Yang Maoqu Chen Wei Feng Lei.RESEARCH PROGRESS OF BIOLOGICAL FUNCTIONS OF SOYBEAN ISOFLAVONE[J].Soybean Science,2006,25(03):320-324.[doi:10.11861/j.issn.1000-9841.2006.03.0320]
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大豆异黄酮的生理功能研究进展*

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第25卷 期数: 2006年03期 页码: 320-324 栏目: 出版日期: 2006-08-25
Title:
RESEARCH PROGRESS OF BIOLOGICAL FUNCTIONS OF SOYBEAN ISOFLAVONE
作者:
杨茂区??1陈 伟 2 冯 　 磊 1
(1. 浙江大学医学院营养与食品安全研究所 ,杭州 310031;2. 浙江体育科学研究所 ,杭州 310031)
Author(s):
Yang Maoqu 1 　 Chen Wei 2 　 Feng Lei 1
(1. Institute of Nutrition and Food Saf ety , Medical College of Zhejiang University , Hangxhou 310031;2.Zhej iang Sports Institute , Hangzhou 310031)
关键词:
大豆; 异黄酮; 生理功能
Keywords:
Soybean ; Isoflavone ; Biological function
DOI:
10.11861/j.issn.1000-9841.2006.03.0320
文献标志码:
A
摘要:
大豆异黄酮是大豆中的一类具有广泛营养学价值和健康保护作用的多酚化合物, 引起了国内外学者的广泛关注 。研究表明, 大豆异黄酮作为一种植物性雌激素 ,具有类雌激素和抗雌激素双重作用,并且在抗肿瘤、预防绝经期妇女骨质疏松症以及预防心血管疾病等方面的作用也得到了流行病学和实验数据的有力支持 。本文对近年来国内外大豆异黄酮的生理功能的相关研究报道进行了分析整理 ,同时对大豆异黄酮的结构、代谢以及发展前景做了介绍。
Abstract:
Soybean isoflavone(SI) is a kind of polyphenols with extensive nutritional values and importantbiological functions, which is much concerned by researchers recently. It was demonstrated that SI playsan important role as a kind of phytoestrogens. And its protective functions for anti-tumor , anti-osteoporo-sis and cardiovascular disease were also supported by a series of epidemical and experimental data. Thestructure , metabolizing and biological functions of SI were summarized in this paper , according to the rela-tive research progress in these years.

参考文献/References:

1　 刘丽, 金宏. 大豆异黄酮抗氧化作用的研究进展[ J] . 中华放射医学与防护杂志, 2003, 4:132- 134.

2　 Zubik L , Mey dani M . Bioavailability of soybean isoflavonesfrom ag lycone and g lucoside forms in American women[ J] . AmJ Clin Nutr, 2003, 77(6):1459 - 1465.
3　 Setchell K. D. R, Cassidy A. Bioavailability of pure isoflavonesin healthy humans and analysis of commercial soy isoflavonesupplements[ J] . J Nutr, 2001, 131(suppl 4):1362S - 1375S.
4　 Watanabe S , Uesugi S, Kikuchi Y. Isoflavones fo r preventionof cancer, cardiovascular diseases, gynecological problems andpossible immune potentiation[ J] . Biomed Pharmacother, 2002,56(6):302 - 312.
5　 Nagata C, T akatsuka N, Kawakami N , et al. Soy product intakeand hot flashes in Japanese women:results from a community-based prospective study[ J] . Am J Epidemiol, 2001, 15, 153(8):790-793.
6　 殷丽君, 李里特, 李再贵. 大豆异黄酮的研究近况与展望[ J] . 食品科学, 2002, 23(4):152 - 154.
7　 Makela SI, Santti R, Salo L , et al. Phytoestrogens are partialestrogen agonists in the adult male mouse[ J] . Environ HealthPerspect , 1995, 103:123.
8　 C. A. MacGreg or, P. A. Canney , G. Patterson, et al. A ran-domized double-blind controlled trial of oral soy supplementsversus placebo for treatment of menopausal symptoms in pa-tients with early breast cancer[ J] . European J Cancer, 2005(41):708 - 714.
9　 Hom Ross P L, Barnes S, Lee M , et al. Assessing phytoestro-gen exposure in epidemiologicstudies:development of a database[ J] . Cancer Cause Control, 2000, 11(4):289.
10 Sarkar F. H. Mechanisms of cancer chemoprevention by soyisoflavone genistein[ J] .Cancer M etastasis Rev , 2002, 21(3- 4):265-280.
11 杨镇洲, 朱俊东, 糜漫天, 等. 大豆异黄酮抑制 Bcap - 37 乳腺癌细胞增殖的作用研究[ J] . 中国公共卫生, 2000,(6):913.
12 刘颖, 张牧, 王小雪, 等. 染料木黄酮对人胃癌细胞生长抑制作用研究[ J] . 营养学报, 2001, 23(1):62.
13 Hesso Farhan, Kristiina Wahala, Herman Adlercreutz, et al.Isoflavonoids inhibit catabolism of viamin D in prostate cancercells[ J] . J Chromat B, 2002,(777):261 - 268.
14 Teruki Oki, Yoshihiro Sowa , Tohru Hirose, et al. Genistein in-duces Gadd45 gene and G2/M cell cycle arrest in the DU145 hu-man prostate cancer cell line[ J] . FEBS Letters, 2004(577):55-59.
15 刘寒强, 王枫. 大豆异黄酮抗肿瘤作用机制研究进展[ J] . 国外医学卫生学分册, 2005, 32 (6):329- 332.
16 Pollard M , Lucher PH. Influence of isoflavone in soy proteinisoflares on development of induced prostate-related cancers inL-W rats[ J] . Nutr Cancer, 1997, 28(1):41.
17 Huachen Wei, Xueshu Zhang , Yan Wang , et al. Inhitition ofultraviolet lig ht-induced oxidative events in the skin and internalorgans of hairless mice by isoflavone genistein[ J] . Cancer letter,2002,(185):21 - 29.
18 Amy L. Hewitt , Keith W. Singetary. Soy ex tract inhibits mam-mary adenocarcinoma growth in a sy ngeneic mouse model[ J] .Cancer Letters, 2003,(192):133- 143.
19 WHO Study Grupe Reprot. Assessment of fracture risk and ap-plication to screening for post me nopausal osteopoeosis[ J] .WHO T ech Rep Ser, 1998, 843:11- 13
20 Ho S C, Woo J, Lam S, et al. Soy protein consumption and bonemass in early postmenopausal Chinese women[ J] . Osteopo rosInt, 2003, 14:835 - 842.
21 Ishimi Y, M. Yoshida , S. Wakimoto , et al. Genistein, a soy-bean isoflavone, affects bone marrow lymphopoiesis and pre-vents bone loss in castrated male mice[ J] . Bone, July 2002 :180- 185.
22 那晓琳, 刘晓华, 崔红斌. 大豆异黄酮对去卵巢大鼠骨力学性能的影响[ J] . 中国公共卫生, 2004, 20(3):264- 265.
23 Morabito N , Crisafulli A , Vergara C, et al. Effect of genisteinand hormone replacement therapy on bone loss in early postm-enopausal women:a randomized double-blind placebo-controlledstudy[ J] . J Bone Miner Res, 2002, 17:1904 - 1912.
24 Bloeden L. T , Jeffcoat A. R, Lopaczynski W, et al. Safety andpharmacokinetics of purified soy isoflavones:single dose admin-istration to postmenopausal women[ J] . Am J Clin Nutr, 2002,76:1126 - 1137.
25 Lichtenstein AH. Soy protein, isoflavones and cardiovasculardisease risk[ J] . J Nutr, 1998, 128 (10):1589- 1592.
26 Behlehole R. Soy protein, isoflavones and cardiovascular diseaserisk[ J] . Epidemiol Rev , 1999,12:1 - 15.
27 Vedavanam K , Bridge PD , Sneath HA , et al. Antioxidant ac-tion and potential antidiabetic properties of an isoflavonoid-con-taining soybean phyto-chemical extract (SPE)[ J] . PhytotherRes, 1999, 13 (7):601 - 608.
28 Sirtori C. R , Lovati M. R. Soy proteins and cardiovascular dis-ease[ J] . Curr Athuroscer Rep, 2001, 3:47.
29 Mary S , Anthony TB, Clarkson CL, et al. Soybean isoflavonesimproves cardio-vascular risk factor without affecting the repro-ductive sy stem of peripubertal rhesus monkeys[ J] . J Nutr,1999, 126:43.
30 Anthony MS , Clarkson TB, Hughes CL, et al. Soybean isofla-vones improve cardiovascular risk factors without affecting thereproductive system of peripubertal rhesus monkey s[ J] . J Nutr,1996, 126(1):43- 50.
31 逢晓云, 姚明辉, 鲁映青, 等. 大豆异黄酮对高胆固醇血症大鼠血及肝脏 MDA 含量和 SOD 活力的影响[ J] . 中国新医药与临床杂志, 2002, 21(5):257.
32 刘锦, 鲁映青. 金雀异黄素对低密度脂蛋白氧化修饰及氧化型低密度脂蛋白诱导的血管内皮细胞 c-myc mRNA 表达的抑制作用[ J] . 中国动脉硬化杂志, 2002, 10(6):509- 514
33 杨科峰, 蔡美琴. 异黄酮对心血管作用的研究进展[ J] . 上海第二医科大学学报, 2005, 5:532 - 534.
34 File S E, Jarrett N , Fluck E, et al. Eating soya improves humanmemo ry[ J] . Psychopharmacology , 2001, 157:430 - 436.
35 Guo T L , Mccay J A , Ling X , et al. Genistein modulates im-mune responses and increases host resistance to B16F10 tumorin adult female B6C3F1 mice[ J] . Nurture , 2001, 131:3251 -3258.
36 White L. R, Petrovitch H , Ross GW, et al. Brain aging andmidlife tofu consumption[ J] . J Am Coll Nutr, 2000, 19:242

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备注/Memo

作者简介:杨茂区(1982 -)男, 硕士研究生, 研究方向:营养与食品卫生学

更新日期/Last Update: 2016-12-16