[1]刘亚文,曹光群,陈婷婷.维生素C脂质体的制备研究[J].大豆科学,2007,26(02):270-272.[doi:10.3969/j.issn.1000-9841.2007.02.031]
　LIU Ya-wen,CAO Guang-qun,CHEN Ting-ting.STUDY ON PREPARATION OF VITAMIN C LIPOSOME[J].Soybean Science,2007,26(02):270-272.[doi:10.3969/j.issn.1000-9841.2007.02.031]
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维生素C脂质体的制备研究

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第26卷 期数: 2007年02期 页码: 270-272 栏目: 出版日期: 2007-04-25
Title:
STUDY ON PREPARATION OF VITAMIN C LIPOSOME
文章编号:
1000-9841(2007)02-0270-03
作者:
刘亚文; 曹光群; 陈婷婷
江南大学化学与材料工程学院，无锡 214036
Author(s):
LIU Ya-wen;  CAO Guang-qun;  CHEN Ting-ting
School of Chemical and Material Engineering，Southern Yangtze University，Wuxi 214036
关键词:
维生素C; 脂质体; 薄膜分散法; 包封率
Keywords:
Vitamin C; Liposome; Film dispersion method; Entrapment efficiency
分类号:
TS224.4
DOI:
10.3969/j.issn.1000-9841.2007.02.031
文献标志码:
A
摘要:
优化制备维生素C脂质体的配方，采用薄膜分散—超声乳化法制备。以包封率为考察指标，经正交优化选择，确定脂质体的最佳配方：卵磷脂/胆固醇/维生素E的摩尔比为4∶2∶0.34；维生素C的浓度为3.3 mg/mL；PBS缓冲液的pH值为7.93；成膜时所用氯仿的量为30 mL，此时包封率可达58.32%。用扫描电子显微镜观察脂质体的结构，平均粒径为310 nm。
Abstract:
To optimize the preparation formulation of vitamin C liposomes,the liposomes were prepared by film dispersion-ultrasonic emulsify method,taking entrapment efficiency as index,and designing an orthogonal experiment.The optimal formulation were: phosphatidylcholine / cholesterin / vitamin E (molar ratio)4∶2∶0.34;vitamin C concentration:3.3 mg/mL;PBS buffer pH value:7.93;chloroform for film forming :30 mL.Under the formulation the entrapment efficiency was 58.32%.The structure of liposome was observed under the scan electronic microscope.The main diameter of the liposome particles was 310 nm.

参考文献/References:

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备注/Memo

作者简介：刘亚文（1980-），女，化学工艺专业硕士研究生。

更新日期/Last Update: 2014-10-22