REN Jiao,SUN Xi-shi,TIAN Jing-ruo,et al.Protection Effect of Soy Isoflavones on Injured Endothelial Cell[J].Soybean Science,2014,33(01):135-138.[doi:10.11861/j.issn.1000-9841.2014.01.0135]
大豆异黄酮对内皮细胞损伤保护作用的研究进展
- Title:
- Protection Effect of Soy Isoflavones on Injured Endothelial Cell
- 文章编号:
- 1000-9841（2014）01-0135-04
- Keywords:
- Soy isoflavones; Endothelial cell; Oxidative damage; Protection
- 分类号:
- R730.2
- 文献标志码:
- A
- 摘要:
- 血管内皮细胞的损伤，会影响血管正常的功能运转，引发高血压、血栓等心血管疾病。大豆异黄酮（soy isoflavones）是一种植物雌性激素，主要存在于豆类植物中，其抗氧化作用可以修复内皮细胞的损伤，对心血管有显著的保护作用。大豆异黄酮对损伤内皮细胞的保护体现在清除自由基、干扰信号通路和影响基因的表达等多个方面。现对大豆异黄酮对损伤血管的保护作用及途径进行了综述，为开发新型内皮细胞保护药物及其临床研究提供理论依据。
- Abstract:
- Soybean isoflavones is a kind of estrogen,mainly exists in legumes.Recently studies have shown that it has many biological activities and pharmcological properties,such as antioxidant,anti-cancer,preventing osteoporosis,menopausal syndrome and cardiovascular protection,and so on.The injury of endothelial cells may lead to cell damage defense system,reduce the ability of scavenging oxygen free radicals and decrease the enzyme activity.Soybean isoflavone has the ability of anti peroxidation and repair the injury of endothelial cells.In this paper,the protection and mechanism of soy isoflavones on injured endothelial cell was summarized,and provided more material basis for the development of new endothelial cell protection drugs and clinical research.
参考文献/References:
[1]井乐刚,路芳.大豆异黄酮的抗氧化活性[J].食品与发酵工业,2004,30(2):62-65.(Jing L G,Lu F.The antioxidant activity of soybean isoflavone[J].Food and Fermentation Industries,2004,30(2):62-65.) [2]刘志胜,李里特.大豆异黄酮及其生理功能研究进展[J].食品工业科技,2000,21(1):78-80.(Liu Z S,Li L T.The research on soybean isoflavones and it’s physiological functions[J].Science and Technology of Food Industry,2000,21(1):78-80.) [3]Ross R.The pathogenesis of atherosclerosis:A perspective for the 1990s[J].Nature,1993,362:801-809. [4]吴旭彤,朱萱萱.中药对血管内皮细胞损伤的保护作用的研究进展[J].中华中医药学刊,2011,29(12):2648-2650.(Wu X T,Zhu X X.The research on traditional Chinese medicine on vascular endothelial cell injury protection[J].Chinese Archives of Traditional Chinese Medicine,2011,29(12):2648-2650.) [5]高玉霞,黄国伟.大豆异黄酮对体外血管内皮细胞氧化损伤保护作用的形态学观察[J].天津医科大学学报,2003,9(1):39-41.(Gao Y X,Huang G W.Protective effect of soybean isoflavone on morphology of vein endothelial cells from oxidative injury in vitro[J].Journal of Tianjin Medical University,2003,9(1):39-41.) [6]黄国伟,曹小红.大豆异黄酮对氧化损伤血管内皮细凋亡作用[J].中国公共卫生,2008,24(7):830-831.(Huang G W,Cao X H.Inhibitive effects of soybean isoflavone on apoptosis of vascular endothelial cells following oxidative injury[J].Chinese Journal of Public Health,2008,24(7):830-831.) [7]郭玮,马丽杰.浅谈大豆异黄酮对血管内细胞氧化的抑制作用[J].求医问药（下半月）,2013,11(1):214-215.(Guo W,Ma L J.Introduction to soy isoflavones on vascular endothelial cells oxidation inhibition[J].Seek Medical and Ask the Medicine（The second half of the month）,2013,11(1):214-215.) [8]何煜舟,丁美萍.大豆异黄酮对氧化损伤的血管内皮细胞的保护作用[J].浙江中医杂志,2006,41(4):228-229.(He Y Z,Ding M P.Soy isoflavones on oxidative damage of endothelial cells of protection[J].Zhejiang Journal of Traditional Chinese Medicine,2006,41(4):228-229.) [9]de Andrade C M,Silva de Sá M F,Toloi Toloi M R,et al.Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC[J].The Journal of the International Menopause Society,2012,15(2):186-94. [10]刘莉,隋艳波.大豆异黄酮对代谢综合征大鼠主动脉内皮细胞功能影响的实验研究[J].中华中医药学刊,2010,28(10):2024-2027.(Liu L,Sui Y B.The influence research of soy isoflavones on endothelial function of metabolic syndrome rats[J].Chinese Archives of Traditional Chinese Medicine,2010,28(10):2024-2027.) [11]逄晓云,沈金芳.大豆异黄酮对大鼠血脂的影响及其体内外抗氧化作用研究[J].中国临床药理学与治疗学,2008,13(1):62-67.(Xiang X Y,Chen J F.The influence of soy isoflavones on blood lipid in rats and its antioxidant effect in vivo and in vitro?studies[J].Chinese Clinical Pharmacology and Therapeutics,2008,13(1):62-67.) [12]张玉梅,刘颖,藤燕平.大豆异黄酮对大鼠实验性粥样硬化动脉壁内粘附分子基因表达的影响[J].中国动脉硬化杂志,2003,11(1):13-15.(Zhang Y M,Liu Y,Teng Y P.Soyisoflavones inhibits gene expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in aorta vessel of atherosclerotic rat predisposed with high cholesterol and high fat diets[J].Chinese Journal of Arterioscler,2003,11(1):13-15.) [13]Fuchs D,Erhard P,Turner R,et al.Genistein reverses changes of the proteome induced by oxidized ox-LDL in EA hy 926 human endothelial cells[J].Journal of Protrome Research,2005,4(2):369-376. [14]Exner M,Hermann M,Hofbauer R,et al.Genistein prevents the glucose autoxidation mediated atherogenic modification of low density lipoprotein[J].Free Radical Research,2001,34(1):101-112. [15]王凡.PPARγ在大豆异黄酮抑制叔丁基过氧化氢诱导人血管内皮细胞氧化应激损伤中的作用研究[D].重庆：第三军医大学,2004.(Wang F.The study on PPARγ of soy isoflavone inhibits cell injury induced by tert-butyl hydroperoxide in human vascular endothelial cell[D].Chongqing:The Third Military Medical University,2004.) [16]Xu S Z,Zhong W W.Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury[J].Free Radical Biology And Medicine,2009,47(2):167-175. [17]Braun M M,Steinberg F M.Soyisoflavones increase antioxidant capacity of endothelial cells[J].Federation of American Societies for Experimental Biology Journal,2003,5(17):A1118. [18]Hernandez-Montes E,Pollard S E.Activation of glutathione peroxidase via?Nrf1 mediates Genistein’s protection against oxidative endothelial cell injury[J].Biochemical and Biophyscial Research Communications,2006,346(3):851-859. [19]Kapiotis S,Hermann M,Held I.Genistein,the dietary-derived angiogenesis inhibitor,prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL[J].Arteriosclerosis Thrombosis and Vascular Biology,1997,17:2868-2874. [20]刘锦,鲁映青.金雀异黄素对低密度脂蛋白氧化修饰及氧化型低密度脂蛋白诱导的血管内皮细胞c-myc mRNA表达的抑制作用[J].中国动脉硬化杂志,2002,10(6):509-512.(Liu J,Lu Y Q.Inhibitory effects of genistein on the oxidative modification of low density lipoprotein and c-myc mRNA expression induced by oxidized low density lipoprotein in vascular endothelial cells[J].Chinese Journal of Arterioscler,2002,10(6):509-512.) [21]Wu X C,Jie M,Wood Carla M.Effect of soy proteins and isoflavones on lipid metabolism and involved gene expression[J].Frontiers in Bioscience Landmark,2008,13(2):2660-2673. [22]吴定,江汉湖.发酵大豆制品中异黄酮形成及其功能[J].中国调味品,2001(6):3-6.(Wu D,Jiang H H.Fermented soy isoflavones in the formation and function[J].Chinese Condiment,2001(6):3-6.) [23]Richard C M S,Francois Y L L,David J R,et al.Cardiovascular targets for estrogens and phytoestrogens:transcriptional regulation of nitric oxide synthase and antioxidant defense genes[J].Free Adical Biology and Medicine,2009,42:909-925. [24]Jacobson M D,Weil M,Raff M C.Programmed cell death in animal development[J].Cell,1997,88(3):347-354. [25]Yu X Y,Zhu J D,Mi M T,et al.Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation[J].Medical Oncology,2012,29(10):349-357. [26]Liu D M,Jiang H L,Robert W.Genistein activates the 3’,5’-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function[J].The Endocrine Society,2005,146(3):1312-1320. [27]吴婷婷,崔桂友,颜云荞,等.8-羟基大豆苷元的生物活性研究进展[J].食品与发酵工业,2012,38(2):141-146.(Wu T T,Cui G Y,Yan Y Q,et al.Progress in the biological activity of 8-OHD[J].Food and Fermentation Industry,2012,38(2):141-146.)
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备注/Memo
基金项目：江苏省普通高校研究生科研创新计划(cxLxl2_0941)。