TIAN Jun-mei,ZHANG Ding,FU Rui-juan,et al.Comparison of the Bioavailability of Soybean Selenoprotein and Sodium Selenite[J].Soybean Science,2010,29(03):534-536.[doi:10.11861/j.issn.1000-9841.2010.03.0534]
大豆硒蛋白与亚硒酸钠生物利用的比较研究
- Title:
- Comparison of the Bioavailability of Soybean Selenoprotein and Sodium Selenite
- 文章编号:
- 1000-9841（2010）03-0534-03
- 分类号:
- R151.2
- 文献标志码:
- A
- 摘要:
- 以雄性SD大鼠为研究对象，建立低硒动物模型，通过灌胃的形式给低硒大鼠补充大豆硒蛋白和亚硒酸钠，检测各组大鼠血、肝、肾中的硒含量与谷胱甘肽过氧化物酶（GSH-Px）和硫氧还蛋白还原酶（TrxR）活性来比较两者的生物利用效果。结果表明：与低硒对照组相比，血、肝、肾中的硒含量以及含硒酶的活性均明显提高（P＜0.05）。亚硒酸钠产生更高的组织硒积累，大豆硒蛋白对含硒酶活性的影响明显高于亚硒酸钠组（P＜0.05）。结果证明大豆硒蛋白具有低毒高效的特点，其吸收利用效果优于亚硒酸钠。
- Abstract:
- The objective of this study was to observe the bioavailability of the soybean selenoprotein with the sodium selenite as reference. Male SD rats were chosen as the experimental object to establish the low-selenium animal model. The rats were given soybean selenoprotein or sodium selenite by intragastric administration. Selenium content, glutathione peroxidase (GSH-Px) and thioredoxin reductase (TrxR) activities in blood, liver and kidney of the rats were determined to compare the bioavailability of the selenoprotein and the sodium selenite. Compared with control group, both the selenium contents and the activities of the selenoenzymes were enhanced significantly (P＜0.05). Much higher tissue selenium accumulation was caused in the sodium selenite group. The activities of the selenoenzymes in the soybean selenoprotein group were higher than that in the sodium selenite group. Results suggest that the soybean selenoprotein is high-efficiency and low-toxicity, and the effects of its absorption and utilization are superior to the sodium selenite.
参考文献/References:
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备注/Memo
第一作者简介：田俊梅（1979-），女，在读硕士，研究方向为营养与食品卫生学。E-mail：yezi_19790908@163.com。