[1]沈丹萍,王小平,秦立强.大豆异黄酮摄入与卵巢癌关系的Meta分析[J].大豆科学,2013,32(06):814-817.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
　SHEN Dan-ping,WANG Xiao-ping,QIN Li-qiang.Isoflavones Intake and Risk of Ovarian Cancer:A Meta Analysis of Epidemiological Study[J].Soybean Science,2013,32(06):814-817.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
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大豆异黄酮摄入与卵巢癌关系的Meta分析

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第32卷 期数: 2013年06期 页码: 814-817 栏目: 出版日期: 2013-12-25
Title:
Isoflavones Intake and Risk of Ovarian Cancer:A Meta Analysis of Epidemiological Study
作者:
?沈丹萍; 王小平; 秦立强
?(苏州大学 公共卫生学院，江苏 苏州 215123)
Author(s):
?SHEN Dan-ping; WANG Xiao-ping; QIN Li-qiang
?(School of Public Health of Soochow University，Suzhou 215123，China)
关键词:
大豆异黄酮; 豆腐; 卵巢癌; Meta分析
Keywords:
(School of Public Health of Soochow University; Suzhou 215123; China)
DOI:
10.11861/j.issn.1000-9841.2013.06.0814
文献标志码:
A
摘要:
?检索了PubMed、中国期刊网等中外文数据库中有关大豆异黄酮/豆制品与卵巢癌关系的病例对照研究和队列研究，并进行Meta分析，研究了大豆异黄酮摄入与卵巢癌发病风险的关系。经筛选，最终有6篇研究纳入了Meta分析。与最低摄取水平比较，最高摄取水平的合并相对危险度（RR）为0.68（95% CI 0.49～0.94），剂量反应关系显示每摄取1.0 mg·d-1大豆异黄酮可降低1.7%的发病风险。富含大豆异黄酮豆腐的合并RR为0.61（0.44～0.85），此Meta分析没有发现明显的发表偏倚。因此，大豆异黄酮摄取可以降低卵巢癌发病风险。
Abstract:
?In order to investigate the relationship between isoflavones intake and the risk of ovarian cancer，casecontrol studies and cohort studies that observed the association of isoflavones/soyfood with ovarian cancer were searched by PubMed，CNKI and other databases.Metaanalysis was performed to calculate summary relative risk(RR).A total of 6 studies were included in the final analysis.The summary RR of ovarian cancer for the highest compared with the lowest isoflavones intake was 0.68(95% CI 0.49-0.94).Doseresponse analysis showed that every 1.0 mg·d-1 increment in isoflavones intake was associated with a significant 1.7% reduction in ovarian cancer risk.The summary RR for bean curd was 0.61(0.44-0.85).There was no obvious publication bias in the Metaanalysis.The results demonstrated that isoflavones intake decreased the risk of ovarian cancer.

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备注/Memo

?国家自然科学基金 (81273067)；“东吴学者计划”高层次人才项目（R5139001）。

更新日期/Last Update: 2014-04-04