[1]陈玉胜.大豆异黄酮抗高尿酸血症活性研究初探[J].大豆科学,2013,32(02):279-282.[doi:10.3969/j.issn.1000-9841.2013.02.032]
　CHEN Yu-sheng.Study on Anti-hyperuricemia Activity of Soybean Isoflavone[J].Soybean Science,2013,32(02):279-282.[doi:10.3969/j.issn.1000-9841.2013.02.032]
点击复制

大豆异黄酮抗高尿酸血症活性研究初探

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第32卷 期数: 2013年02期 页码: 279-282 栏目: 出版日期: 2013-04-25
Title:
Study on Anti-hyperuricemia Activity of Soybean Isoflavone
作者:
陈玉胜
（南京晓庄学院 生物化工与环境工程学院，江苏 南京 211171）
Author(s):
CHEN Yu-sheng
（School of Biochemical and Environmental Engineering，Nanjing Xiaozhuang University，Nanjing 211171，China）
关键词:
大豆异黄酮; 高尿酸血症; 氧嗪酸钾盐; 小鼠
Keywords:
Soybean isoflavone; Hyperuricemia; Potassium oxonate; Mice
DOI:
10.3969/j.issn.1000-9841.2013.02.032
文献标志码:
A
摘要:
为研制新型无副作用的降血尿酸药物，在氧嗪酸钾盐诱导小鼠产生高尿酸血症模型的基础上，探讨大豆异黄酮的抗高尿酸活性。将昆明雄性小鼠随机分为6组，即正常对照组、高尿酸血症模型对照组、模型给药组（分为大豆异黄酮 25，50和100 mg·kg-1剂量组、别嘌醇5 mg·kg-1剂量组）。连续7 d每天灌胃氧嗪酸钾盐(250 mg·kg-1)1 h后灌胃给药。分别测定血清尿酸、肌酐与尿素氮水平及尿液尿酸和肌酐水平。结果表明：与高尿酸血症模型组相比，大豆异黄酮显著或极显著降低高尿酸血症小鼠血清尿酸、肌酐和尿素氮水平，提高24 h尿液尿酸和肌酐排泄量以及尿酸排泄分数。综合考虑，大豆异黄酮通过促进肾脏尿酸排泄作用，从而体现抗高尿酸活性。
Abstract:
The anti-hyperuricemia activity of soybean isoflavone in hyperuricemic mice induced by potassium oxonate was discussed.Kunming male mice were divided randomly into normal control group，and 5 hyperuricemic groups with model control，5 mg·kg-1 allopurinol and 25，50，100 mg·kg-1soybean isoflavone.Mice were orally administered once daily with 250 mg·kg-1 potassium oxonate for 7 continuous days to create the model.Three doses of soybean isoflavone were orally initiated on the day 1 h after potassium oxonate was given，separately.Serum uric acid，creatinine and urea nitrogon levels，as well as urinary uric acid and creatinine levels were measured.The results indicated that，compared with model group，soybean isoflavone significantly reduced serum uric acid，creatinine and urea nitrogon levels，increased 24 h uric acid and creatinine excretion，and fractional excretion of uric acid in hyperuricemic mice.In conclusion，the antihyperuricemia effect of soybean isoflavone was attributed to uric acid excretion enhancement.

相似文献/References:

[1]徐美蓉,李玉芳,董煚,等.大豆异黄酮超声波辅助提取条件优化的研究[J].大豆科学,2013,32(01):102.[doi:10.3969/j.issn.1000-9841.2013.01.024]
　XU Mei-rong,LI Yu-fang,DONG Jiong,et al.Optimization of Soy Isoflavone Extraction Assisted with Ultrasonic[J].Soybean Science,2013,32(02):102.[doi:10.3969/j.issn.1000-9841.2013.01.024]
[2]沈丹萍,王小平,秦立强.大豆异黄酮摄入与卵巢癌关系的Meta分析[J].大豆科学,2013,32(06):814.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
　SHEN Dan-ping,WANG Xiao-ping,QIN Li-qiang.Isoflavones Intake and Risk of Ovarian Cancer:A Meta Analysis of Epidemiological Study[J].Soybean Science,2013,32(02):814.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
[3]何恩铭,沈瑞池,王 伟,等.紫外分光光度法测定豆渣提取物中大豆异黄酮含量的研究[J].大豆科学,2013,32(06):818.[doi:10.11861/j.issn.1000-9841.2013.06.0818]
　HE En-ming,SHEN Rui-chi,WANG Wei,et al.Determination of Isoflavones in Extraction of Soybean Dregs Using Ultraviolet Spectrophotometry[J].Soybean Science,2013,32(02):818.[doi:10.11861/j.issn.1000-9841.2013.06.0818]
[4]彭 游,喻国贞,郎少杰,等.新型大豆异黄酮萘磺酸酯前药的设计合成[J].大豆科学,2013,32(06):854.[doi:10.11861/j.issn.1000-9841.2013.06.0854]
　PENG You,YU Guo-zhen,LANG Shao-jie,et al.Design and Synthesis of Novel Genistein Naphthylsulfonate Prodrugs[J].Soybean Science,2013,32(02):854.[doi:10.11861/j.issn.1000-9841.2013.06.0854]
[5]刘少静,王多宁,刁颖博,等.大豆异黄酮纯化工艺研究[J].大豆科学,2013,32(04):535.[doi:10.11861/j.issn.1000-9841.2013.04.0535]
　LIU Shao-jing,WANG Duo-ning,DIAO Ying-bo,et al.Optimization on the Purification Technologies of Soybean Isoflavone[J].Soybean Science,2013,32(02):535.[doi:10.11861/j.issn.1000-9841.2013.04.0535]
[6]尹学哲,金延华,金梅花,等.大豆异黄酮对内毒素及D-氨基半乳糖所致小鼠急性肝损伤的保护作用[J].大豆科学,2013,32(04):544.[doi:10.11861/j.issn.1000-9841.2013.04.0544]
　YIN Xue-zhe,JIN Yan-hua,JIN Mei-hua,et al.Protective Effects of Soy Isoflavones on Acute Liver Injury Induced by Lipopolysaccharide and D-galactosamine in Mice[J].Soybean Science,2013,32(02):544.[doi:10.11861/j.issn.1000-9841.2013.04.0544]
[7]董军奎,葛晓月.大豆异黄酮：一种多功能植物药[J].大豆科学,2013,32(04):565.[doi:10.11861/j.issn.1000-9841.2013.04.0565]
　DONG Jun-kui,GE Xiao-yue.Soy Isoflavone:The Multipurpose Phytopharm[J].Soybean Science,2013,32(02):565.[doi:10.11861/j.issn.1000-9841.2013.04.0565]
[8]李怡然,赵丽芹,李爱科,等.豆浆中水溶性大豆异黄酮检测方法的建立[J].大豆科学,2014,33(03):429.[doi:10.11861/j.issn.1000-9841.2014.03.0429]
　LI Yi-ran,ZHAO Li-qin,LI Ai-ke,et al.Construction of Detection Method for Water soluble Isoflavone Content in Soybean Milk[J].Soybean Science,2014,33(02):429.[doi:10.11861/j.issn.1000-9841.2014.03.0429]
[9]刘中华,胡春红,郭 婕,等.低温豆粕中异黄酮和皂甙的微波同步提取工艺[J].大豆科学,2014,33(03):443.[doi:10.11861/j.issn.1000-9841.2014.03.0443]
　LIU Zhong-hua,HU Chun-hong,GUO Jie,et al.Microwave Extraction of Isoflavones and Saponins in the Low temperature ?Soybean Meal[J].Soybean Science,2014,33(02):443.[doi:10.11861/j.issn.1000-9841.2014.03.0443]
[10]张晓燕,鲁燕舞,魏圣军,等.光质对大豆芽苗菜生长和大豆异黄酮含量及PAL活性的影响[J].大豆科学,2014,33(01):46.[doi:10.11861/j.issn.1000-9841.2014.01.0046]
　ZHANG Xiao yan,LU Yan wu,WEI Sheng jun,et al.Effects of Light Quality on Growth,Soy Isoflavone Content and PAL Activity of Soybean Sprouts[J].Soybean Science,2014,33(02):46.[doi:10.11861/j.issn.1000-9841.2014.01.0046]

备注/Memo

?江苏省高等学校大学生实践创新项目（2160081）。

更新日期/Last Update: 2014-04-03