[1]任彦荣,李晓波,陈晓麟.结肠靶向大豆异黄酮缓释微丸胶囊的制备及体外释放研究[J].大豆科学,2008,27(05):895-897.[doi:10.11861/j.issn.1000-9841.2008.05.0895]
　REN Yan-rong,LI Xiao-bo,CHEN Xiao-lin.Preparation and in Vitro Dissolution of Soybean Isoflavone Colon Targeting Sustained-Release Pellet Capsules[J].Soybean Science,2008,27(05):895-897.[doi:10.11861/j.issn.1000-9841.2008.05.0895]
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结肠靶向大豆异黄酮缓释微丸胶囊的制备及体外释放研究

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第27卷 期数: 2008年05期 页码: 895-897 栏目: 出版日期: 2008-10-25
Title:
Preparation and in Vitro Dissolution of Soybean Isoflavone Colon Targeting Sustained-Release Pellet Capsules
文章编号:
1000-9841(2008)05-0895-03
作者:
任彦荣1; 2; 李晓波2; 陈晓麟2
1重庆大学生物工程学院，重庆 400044；
2重庆教育学院，重庆 400067
Author(s):
REN Yan-rong1; 2; LI Xiao-bo2; CHEN Xiao-lin2
1 College of Bioengineering，Chongqing University，Chongqing 400044；
2Chongqing Education College，Chongqing 400067，China
关键词:
结肠靶向; 大豆异黄酮; 缓释微丸胶囊; 体外释放
Keywords:
Colon targeting; Soybean isoflavone; Sustained-release pellet capsules; In vitro dissolution
分类号:
Q977.9
DOI:
10.11861/j.issn.1000-9841.2008.05.0895
文献标志码:
A
摘要:
对结肠靶向大豆异黄酮缓释微丸胶囊的处方和工艺进行考察，并考察其体外释放行为。以胶囊释放度作为考察指标，采用正交设计试验优化处方和工艺。大豆异黄酮缓释微丸胶囊的最优处方为大豆异黄酮5 g，羟丙甲纤维素为6 g，乙基纤维素为7 g，微晶纤维素为6 g，滚圆时间为20 min，黏合剂为以50%乙醇溶液，所制微丸圆整度好，平面临界角12.4°，收率93.8 %，释药行为符合一级释药方程，具有明显的缓释特征。大豆异黄酮缓释微丸胶囊具有良好的体外缓释效果。
Abstract:
To study the formulation and processing of soybean isoflavone colon targeting sustained-release pellet capsules，and to evaluate its release behavior in vitro.The pellets were prepared by extrusion/spheronization.Orthogonal design was used to screen the formulation of soybean isoflavone sustained-release pellet capsules and to optimize the manufacturing process.The optimized formulation of soybean isoflavone sustained-release pellet capsules and processing followed as:5 g of soybean isoflavone，6 g of HPMC(Hydroxypropyl Methyl Cellulose),7 g of EC(Ethyl Cellulose),6 g of MCC(Microcrystalline Cellulose)，the time of spheronization was 20 min，and 50 % alcohol as adhesive.The prepared pellets had good spheronization，the critical angle of plan was 12.4 and the recovery was 93.8 %.Moreover，in vitro release of soybean isoflavone sustained-release pellet capsules properly described by first-order kinetics and the sustained-release of the pellets was evident.The colon targeting sustained-release soybean isoflavone pellets capsules with in vitro sustained release characteristics were successfully prepared.

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备注/Memo

基金项目：重庆市教育委员会资助项目（KJ071505）。

作者简介：任彦荣（1980-），女，讲师，博士，主要从事制药工程的科研与教学工作。E-mail：cquryr@126.com。

更新日期/Last Update: 2014-10-06