[1]刘春龙,李忠秋,孙海霞,等.大豆异黄酮的生理作用及其在医学方面的研究进展[J].大豆科学,2008,27(04):693-696.[doi:10.11861/j.issn.1000-9841.2008.04.0693]
　LIU Chun-long,LI Zhong-qiu,SUN Hai-xia,et al.Research Progress and Physiological Function of Soybean Isoflavone on Medicine[J].Soybean Science,2008,27(04):693-696.[doi:10.11861/j.issn.1000-9841.2008.04.0693]
点击复制

大豆异黄酮的生理作用及其在医学方面的研究进展

《大豆科学》[ISSN:1000-9841/CN:23-1227/S] 卷: 第27卷 期数: 2008年04期 页码: 693-696 栏目: 出版日期: 2008-08-25
Title:
Research Progress and Physiological Function of Soybean Isoflavone on Medicine
文章编号:
1000-9841(2008)04-0693-04
作者:
刘春龙1; 2; 李忠秋3; 孙海霞1; 李长胜1
1中国科学院东北地理与农业生态研究所，黑龙江省黑土生态重点实验室，黑龙江 哈尔滨 150081；
2东北农业大学动物科技学院，黑龙江 哈尔滨 150030；
3黑龙江省农业科学院畜牧研究中心，黑龙江 哈尔滨 150086
Author(s):
LIU Chun-long1; 2; LI Zhong-qiu3; SUN Hai-xia1; LI Chang-sheng1
1Heilongjiang Key Laboratory of Blacksoil Ecology，Northeast Institute of Geography and Agricultural Ecology,Chinese Academy of Sciences，Harbin 150081；
2College of Animal Science，Northeast Agricultural University，Harbin 150030；
3 Animal Science Research Centre，Heilongjiang Academy of Agricultural Sciences，Harbin 150086，Heilongjiang，China
关键词:
大豆异黄酮; 生理作用; 医学; 研究进展
Keywords:
Soybean isoflavone; Physiological function; Mdecine; Research progress
分类号:
TS201.2
DOI:
10.11861/j.issn.1000-9841.2008.04.0693
文献标志码:
A
摘要:
大豆异黄酮是大豆生长过程中形成的一类次级代谢产物。近年来研究发现大豆异黄酮在预防癌症、骨质疏松症、心血管疾病和改善妇女更年期综合症等方面具有广泛的生物效应，现对其生理作用及在医学方面的研究进展予以综述。
Abstract:
Soybean isoflavones is one of hypo-metabolize production which produced during soybean growth progress.In recent years，many researches had reported that it can prevent cancer，osteoporosis，cardiovascular diseases and menopausal women symptoms.This paper mainly introduced the physiological effects and research progress of soybean isoflavone on domestic and overseas literatures.

参考文献/References:

[1]孙艳,庄逢源.大豆异黄酮的微生物转化[J].微生物学通报，2005,32(5):147-150.（Sun Y，Zhuang F Y.Soybean isoflovone and microbes[J].Microbiology,2005,32⑸:147-150.）

[2]Lu L J W，Anderson K E，Grady J J，et al.Decreased ovaria hormones during a soya diet:implications for breast cancer prevention[J].Cancer Research，2000,60:4112-4121.
[3]Teede H J，Dalais F S，Kotsopoulos D，et al.Dietary soy has both beneficial and potentially adverse cardiovascular effects:a placebo controlled study in men and postmenopausal women [J].Journal of Clinical Endocrinology & Metabolism，2001,86:3053-3060.
[4]Watanabe S，Uesugi S，Kikuchi Y.Isoflavones for prevention of cancer，cardiovascular diseases，gynecological problems and possible immune potentiation[J].Biomedicine & Pharmacotherapy，2001,56:302-312.
[5]Zittermann A，Geppert J，Baier S，et al.Short-tern effects of high soy supplementation on sex hormones，bone markers，and lipid parameters in young female adults[J].European Journal of Nutrition，2004,43:100-108.
[6]虞丹.植物雌激素-大豆异黄酮的药理作用研究概况[J].海峡药学，2007,19(2):9-12.(Yu D.Research of isoflavone on pharmacology [J].Strait Pharmaceutical Journal，2007,19(2):9-12.)
[7] Messina M J，Persky V，Setchell K D R，et al.Soyintake and cancer risk：a rewiew of the in vitro and in vivo data[J].Nutr Cancer，1994,21:l13-131.
[8]Horn-Ross P L，Barnes S，Lee M，et al.Assessing phytoeatrogen exposure in epidimiologic studies development of a database[J].Cancer Causes and Control，2000,11(4):280-109.
[9]Sarkar F H,Li Y W.Mechanisms of cancer chemoprevention by soy isoflavone genistein[J].Cancer and Metastasis Reviews,2002,21(3):265-280.
[10]Ganry O.Phytoestrogen and breast cancer prevention[J].European Journal of Cancer Prevention，2002,11(6):519-522.
[11]余小平,糜漫天,朱俊东,等.染料木黄酮对MDAMB-453乳腺癌细胞VEGF表达的影响[J].营养学报，2005,4:322-324.(Yu X,Mi M T,Zhu J D.Effect of genistein on expression of vascular endothelial growth factor in MDA-MB453 breast cancer cells[J].Acta Nutrimenta Sinica，2005,4:322-324.)
[12]Morton M S, Arisaka O, Miyake N，et al.Phytoestrogen concentrations in serum from Japanese men and women over forty years of age[J].Journal of Nutrition，2002,132(10):3168-3171.
[13]Akiyama T，Ishida J，Nakagawa S，et al.Genistein，a specific inhibitor of tyrosine-specific protein kinases［J］.Journal of Biological Chemistry，1987,262(12):5592-5595.
[14]Messina M.Soyfoods and soybean phytooestrogens(isoflavones)as possible alternatives to hormone replacement therapy(HRT)[J].EuropeanJournal of Cancer,2000,36:71-77.
[15]Kang H J，Ansbacher R，Hammoud M M.Use of alternative and complementary medicine in menopause.International[J].Journal of Gynecology and Obstetrics,2002,79:195-207.
[16]Sugimoto E,Yamaguchi M.Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cell[J].Biochemical Pharmacology,2000,59(5):471-475.[17]Rassi C M，Lieberherr M，Chaumaz G，et al.Down-regulation of osteoclast differentiation by daidzein via caspase 3[J].Journal of Bone and Mineral Research,2002,17(4):630-638.
[18]史琳娜,苏宜香.大豆异黄酮类对去卵巢大鼠骨丢失的影响[J].营养学报,2000,22⑵:113-118.(Shi L N,Su Y X.The influence of soybean isoflavones on bone loss in ovariectomized female rats[J].Acta Nutrimenta Sinica，,2000,22(2):113-118.)
[19]那晓琳,刘晓华,崔红斌.大豆异黄酮对去卵巢大鼠骨力学性能的影响[J].中国公共卫生,2004,20(3):264-265.(Na X L，Liu X H，Cui H B.Effects of soybean isoflavone on bone biomechanics in ovariectomized rats[J].Chinese Journal of Public Health，2004,20(3):264-265.)
[20]王晓炜,程光宇,吴京燕,等.大豆异黄酮和牛初乳复合制剂对去卵巢大鼠骨密度及子宫组织抗氧化作用的研究 [J].食品科学,2007,28(2):297-302.(Wang X W,Cheng G Y,Wu J Y,et al.Effects of complexes of soy isoflavones and bovine colostrum(SIBC)on bone density and anti-oxidant of uterus in OVX Rats [J].Food Science，2007,28(2):297-302.)
[21]张玉梅,滕燕平,邱隽,等.大豆异黄酮抗高脂型大鼠主动脉血管壁粥样硬化斑块形成研究[J].中国预防医学杂志,2003,4⑴:1-4.(Zhang Y M,Teng Y P,Qiu J,et al.Soy Isoflavones Inhibits atherosclerotic plaque formation in aorta of hypercholesterolemia rats and regulates gene expression of inducible nitric oxide synthase and adhesion molecules [J].China Preventive Medicine,2003,4(1):1-4.)
[22]尹学哲,全吉淑,金泽武道,等.大豆异黄酮和皂甙对糖尿病大鼠抗动脉粥样硬化活性的研究[J].中华预防医学杂志,2004,38(1):26-28.(Yin X Z，Quan J S，Takemichi K,et al.Anti-atherosclerotic effect of soybean isofalvones and soyasaponins in diabetic rats[J].ChinaPreventive Medicine,2004,38(1):26-28.)
[23] McElwee K J，Niiyama S，Freyschmidt-Paul P，et al.Dietary soy oil content and soyderi-ved phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice[J].Experimental Dermatology,2003,12（1）：30-36.
[24]冯晓凡,陈世伟,张立实.大豆异黄酮对肥胖大鼠血脂及瘦素水平的影响[J].现代预防医学,2006,33(2):131-132.(Feng X F,Chen S W，Zhang L S.The effect of soy isoflavones on the level of blood lipid and leptin of the obese rats[J].Modern Preventive Medicine，2006,33(2):131-132.)
[25]Rivas M,Garay R P,Escanero J F.Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension[J].Journal of Nutrition,2002,132⑺:1900-1902.

相似文献/References:

[1]徐美蓉,李玉芳,董煚,等.大豆异黄酮超声波辅助提取条件优化的研究[J].大豆科学,2013,32(01):102.[doi:10.3969/j.issn.1000-9841.2013.01.024]
　XU Mei-rong,LI Yu-fang,DONG Jiong,et al.Optimization of Soy Isoflavone Extraction Assisted with Ultrasonic[J].Soybean Science,2013,32(04):102.[doi:10.3969/j.issn.1000-9841.2013.01.024]
[2]陈玉胜.大豆异黄酮抗高尿酸血症活性研究初探[J].大豆科学,2013,32(02):279.[doi:10.3969/j.issn.1000-9841.2013.02.032]
　CHEN Yu-sheng.Study on Anti-hyperuricemia Activity of Soybean Isoflavone[J].Soybean Science,2013,32(04):279.[doi:10.3969/j.issn.1000-9841.2013.02.032]
[3]沈丹萍,王小平,秦立强.大豆异黄酮摄入与卵巢癌关系的Meta分析[J].大豆科学,2013,32(06):814.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
　SHEN Dan-ping,WANG Xiao-ping,QIN Li-qiang.Isoflavones Intake and Risk of Ovarian Cancer:A Meta Analysis of Epidemiological Study[J].Soybean Science,2013,32(04):814.[doi:10.11861/j.issn.1000-9841.2013.06.0814]
[4]何恩铭,沈瑞池,王 伟,等.紫外分光光度法测定豆渣提取物中大豆异黄酮含量的研究[J].大豆科学,2013,32(06):818.[doi:10.11861/j.issn.1000-9841.2013.06.0818]
　HE En-ming,SHEN Rui-chi,WANG Wei,et al.Determination of Isoflavones in Extraction of Soybean Dregs Using Ultraviolet Spectrophotometry[J].Soybean Science,2013,32(04):818.[doi:10.11861/j.issn.1000-9841.2013.06.0818]
[5]彭 游,喻国贞,郎少杰,等.新型大豆异黄酮萘磺酸酯前药的设计合成[J].大豆科学,2013,32(06):854.[doi:10.11861/j.issn.1000-9841.2013.06.0854]
　PENG You,YU Guo-zhen,LANG Shao-jie,et al.Design and Synthesis of Novel Genistein Naphthylsulfonate Prodrugs[J].Soybean Science,2013,32(04):854.[doi:10.11861/j.issn.1000-9841.2013.06.0854]
[6]刘少静,王多宁,刁颖博,等.大豆异黄酮纯化工艺研究[J].大豆科学,2013,32(04):535.[doi:10.11861/j.issn.1000-9841.2013.04.0535]
　LIU Shao-jing,WANG Duo-ning,DIAO Ying-bo,et al.Optimization on the Purification Technologies of Soybean Isoflavone[J].Soybean Science,2013,32(04):535.[doi:10.11861/j.issn.1000-9841.2013.04.0535]
[7]尹学哲,金延华,金梅花,等.大豆异黄酮对内毒素及D-氨基半乳糖所致小鼠急性肝损伤的保护作用[J].大豆科学,2013,32(04):544.[doi:10.11861/j.issn.1000-9841.2013.04.0544]
　YIN Xue-zhe,JIN Yan-hua,JIN Mei-hua,et al.Protective Effects of Soy Isoflavones on Acute Liver Injury Induced by Lipopolysaccharide and D-galactosamine in Mice[J].Soybean Science,2013,32(04):544.[doi:10.11861/j.issn.1000-9841.2013.04.0544]
[8]董军奎,葛晓月.大豆异黄酮：一种多功能植物药[J].大豆科学,2013,32(04):565.[doi:10.11861/j.issn.1000-9841.2013.04.0565]
　DONG Jun-kui,GE Xiao-yue.Soy Isoflavone:The Multipurpose Phytopharm[J].Soybean Science,2013,32(04):565.[doi:10.11861/j.issn.1000-9841.2013.04.0565]
[9]李怡然,赵丽芹,李爱科,等.豆浆中水溶性大豆异黄酮检测方法的建立[J].大豆科学,2014,33(03):429.[doi:10.11861/j.issn.1000-9841.2014.03.0429]
　LI Yi-ran,ZHAO Li-qin,LI Ai-ke,et al.Construction of Detection Method for Water soluble Isoflavone Content in Soybean Milk[J].Soybean Science,2014,33(04):429.[doi:10.11861/j.issn.1000-9841.2014.03.0429]
[10]刘中华,胡春红,郭 婕,等.低温豆粕中异黄酮和皂甙的微波同步提取工艺[J].大豆科学,2014,33(03):443.[doi:10.11861/j.issn.1000-9841.2014.03.0443]
　LIU Zhong-hua,HU Chun-hong,GUO Jie,et al.Microwave Extraction of Isoflavones and Saponins in the Low temperature ?Soybean Meal[J].Soybean Science,2014,33(04):443.[doi:10.11861/j.issn.1000-9841.2014.03.0443]

备注/Memo

基金项目：哈尔滨市青年科技创新人才专项基金资助项目（2006RFQYN111）；黑龙江省教育厅重大计划资助项目（10541z003）；国家科技支撑计划资助项目（2006BAD04A03-02）。

作者简介：刘春龙（1976-），男，博士。主要从事反刍动物营养方向的研究工作。

更新日期/Last Update: 2014-10-07