|Table of Contents|

Protective Effects of S-equol on Depressive-like Behavior Induced by Chronic Unpredictable Mild Stress in Mice(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2022年06期
Page:
726-732
Research Field:
Publishing date:

Info

Title:
Protective Effects of S-equol on Depressive-like Behavior Induced by Chronic Unpredictable Mild Stress in Mice
Author(s):
ZHANG Ying-yu1;  WEI Zhen1;  REN Zi-yi1;  LIU Jia-meng1;  SUN Jing1;  FAN Bei1;  LIU Xin-min2;  LU Cong1;  WANG Feng-zhong1
(1.Institute of Food Science and Technology， Chinese Academy of Agricultural Sciences， Beijing 100193， China; 2.Institute of Medicinal Plants， Chinese Academy of Medical Science， Beijing 100193， China)
Keywords:
S-equol;  chronic unpredictable mild stress;  hypothalamic-pituitary-adrenal axis
PACS:
-
DOI:
10.11861/j.issn.1000-9841.2022.06.0726
Abstract:
In order to explore the ameliorating effects of S-equol (Eq) on depressive-like behavior induced by chronic unpredictable mild stress (CUMS)， mice were randomly divided into control group (Con)， CUMS model group (CUMS)， Eq-Low group (Eq-L， 10 mg·kg-1)， Eq-Medium group (Eq-M， 20 mg·kg-1) and Eq-High group (Eq-M， 40 mg·kg-1). After pre-administration with Eq for 14 days， the CUMS group and Eq groups were conducted by continue stress for 42 days. The antidepressant effect of Eq was investigated by body weight (BW)， open field test (OFT)， sucrose preference test (SPT)， tail suspension test (TST)， forced swimming test (FST) and novelty‐suppressed feeding test (NFT). In addition， the level of corticosterone (CORT) in serum of mice was measured to explore the molecular mechanism of its antidepressant action. The results of behavioral tests showed that CUMS had no influence on the locomotor activity of mice compared to those of control group， the body weight and sucrose preference index of the CUMS-treated mice was significantly decreased， the immobility time in TST and FST and the latency time in NFT was significantly prolonged. Administration with Eq also had no influence on the locomotor activity of mice compared to the model group， while the body weight and sucrose preference index of the Eq-treated mice were significantly improved， the immobility time in TST and FST and the latency time in NFT were significantly shortened. Moreover， CUMS treatment significantly increased the levels of CORT in serum， however， Eq administration significantly reversed this change. These findings demonstrated that Eq treatment significantly alleviated the depressive-like behavior induced by CUMS， and the antidepressant-like effects of Eq may be related to normalize the hypothalamic-pituitary-adrenal axis (HPA).

References:

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Last Update: 2022-11-29