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Studies on the Preparation and Anticancer Activity of Genistein Zinc and Genistein Copper Complexes(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2022年01期
Page:
91-098
Research Field:
Publishing date:

Info

Title:
Studies on the Preparation and Anticancer Activity of Genistein Zinc and Genistein Copper Complexes
Author(s):
WANG You-di1 PENG Jun-mei2 LIU Ming-mei1 XU Juan-juan1
(1.School of Pharmacy, Guangzhou Xinhua University, Guangzhou 510520, China; 2.College of Pharmacy, University of South China, Hengyang 421001, China)
Keywords:
soybean genistein zinc complexe copper complexe synthesis anticancer activity
PACS:
-
DOI:
10.11861/j.issn.1000-9841.2022.01.0091
Abstract:
In order to study the preparation method and anticancer activity of genistein-zinc and genistein-copper metal complexes, genistein was used as a ligand, and then it was combined with zinc and copper to synthesize genistein-zinc and genistein-copper metal complexes. Metal complexes were characterized by IR, UV and thermogravimetric analysis. The inhibitory effects of genistein and its zinc and copper complexes on the proliferation of human non-small cell lung cancer cell line A549, human breast cancer cell MCF-7 and human umbilical vein endothelial cell HUVEC were investigated by MTT method. The results showed that genistein-zinc and genistein-copper complexes were successfully prepared, and the MTT assay results showed that genistein-zinc and genistein-copper complexes had inhibitory effects on the proliferation of MCF-7 and A549 cells, and the inhibitory effects were higher than genistein, however, genistein-zinc and genistein-copper complexes had no obvious inhibitory effects on the proliferation of HUVEC cells. Keywords:

References:

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Last Update: 2022-01-28