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Study on Apsorption of Daidzein Sulfonic Acid Ester on HAVSMCs and the Relationship Between Pharmaceutical Properties and Structure(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2019年01期
Page:
97-103
Research Field:
Publishing date:

Info

Title:
Study on Apsorption of Daidzein Sulfonic Acid Ester on HAVSMCs and the Relationship Between Pharmaceutical Properties and Structure
Author(s):
PENG You1;  XIONG Xiao-wei2;  HU Hua-nan1;  HUANG Hua-nan1
(1.Jiangxi Province Engineering Research Center of Ecological Chemical Industry, Jiujiang University, Jiujiang 332005, China; 2. School of Pharmacy, Nanchang University, Nanchang 330000, China)
Keywords:
Daidzein;  Benzene sulfonate;  Cell absorption;  Liposolubility;  Water solubility;  Structure properties relationship
PACS:
-
DOI:
10.11861/j.issn.1000-9841.2019.01.0097
Abstract:
To improve the effect of daidzein inhibiting the atherosclerosis, its structure was modified using the principle of pharmacokinetic group and its sulfonate derivatives(D1,D2) were synthesized. The pharmacological properties of the target derivatives were investigated by HPLC and ChemAxon. The absorptivity of daidzein and its derivatives were investigated by HAVSMCs and HPLC. The results showed that absorptivity on HAVSMCs of DD, its derivatives D1, D2 were maxmum with 20.3%、29.4% and 71.7% respectively and the maximum absorptivity were D2>D1>DD. The study on relationship of structure and properties showed that the absorption and utilization of drugs were closely related to the physicochemical properties of the drugs, and the absorption and utilization of the drugs on cells were optimal only with moderate liposolubility and water solubility.

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Last Update: 2019-01-22