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Anti-tumor and Pro-apoptotic Effects of Soy Isoflavones and Saponins on H22-bearing Mice(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2016年03期
Page:
494-497
Research Field:
Publishing date:

Info

Title:
Anti-tumor and Pro-apoptotic Effects of Soy Isoflavones and Saponins on H22-bearing Mice
Author(s):
ZHENG Feng; JIN Yan-hua; HE Xin; QUAN Ji-shu; YIN Xue-zhe
1. Yanbian University Hospital，Yanji 133002，China;?
2. Yanbian University Medical College，Yanji 133000，China
Keywords:
Soy isoflavones;  Saponins;  H22;  Anti-tumor
PACS:
Ｒ285. 5
DOI:
10.11861/j.issn.1000-9841.2016.03.0494
Abstract:
The anti-tumor and pro-apoptotic effects of soy isoflavones and saponins on H22-bearing mice were investigated.Mice bearing H22 hepatoma cells were randomly assigned into 4 groups including model，5-Fu，isoflavone and soyasaponingroups. Animals were treated with ig 200 mg·kg － 1 of soy isoflavones and saponins once daily for 10 days，and with ig 5-Fu 25mg·kg － 1 every other day for 3 times. At the end of experiment，the tumor growth inhibition ratios，spleen and thymus indexeswere calculated，the pathological changes were detected with hematoxylin ＆ eosin( HE) staining，and the relative activities ofCaspase-3 and Caspase-8，as well as the serum levels of reduced glutathione( GSH) ，the total antioxidant capacity( T-AOC)and malondialdehyde( MDA) were detected by the colorimetric method. The results showed that the administration with soyisoflavones and saponins inhibited the growth of transplanted tumor with the inhibitory ratios of 36. 3% and 34. 8%，respectively.In addition，soy isoflavones and saponin treatment elevated the spleen index，increased the relative activities ofCaspase-3 and Caspase-8 of tumor tissue，decreased the serum MDA，and increased the serum GSH and T-AOC of H22-bearingmice. It is suggested that soy isoflavones and saponins could exhibit the inhibitory effects on the transplanted H22 tumor inmice，probably via pro-apoptotic and anti-oxidative activities.

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Last Update: 2016-07-24