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Antioxidant Effect of Soybean Water Extracts (SWEs) on Acute Liver Injury induced by CCl4?in Mice(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2015年02期
Page:
341-344
Research Field:
Publishing date:

Info

Title:
Antioxidant Effect of Soybean Water Extracts (SWEs) on Acute Liver Injury induced by CCl4?in Mice
Author(s):
CHEN Yu-sheng; CHEN Quan-zhan
School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University, Nanjing 211171, China
Keywords:
Soybean water extracts (SWEs);  Liver injury;  Antioxidant;  Bifendate
PACS:
S565.1
DOI:
10.11861/j.issn.1000-9841.2015.02.0341
Abstract:
To explore the protective effects of soybean water extracts (SWEs) on acute liver damage induced by carbon tetrachloride (CCl4) in mice Sixty mice were randomly divided into control group, model group and SWEs groups at dose of 50, 100 and 150 mg?kg-1, and positive control group (bifendate, 100 mg?kg-1) All the mice were intragastrically administrated the corresponding agents respectively once a day for 7 days One hour after the administration, 10% CCl4?2.0 mL?kg-1 was given to mice in all groups except the control group, with a single intraperitoneal injection to establish the acute liver injury mouse model. Six hours later, mice were sacrificed, and the liver index, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, total bilirubin (TBIL) and albumin (ALB) level in serum were detected; the malondialdehyde (MDA) and glutathione (GSH) levels, and nitric oxide synthase (NOS) activity in liver tissue were also analyzed Results indicated that CCl4?significantly increased the liver weight, liver index, and levels of ALT, AST and TBIL in serum, MDA and NOS in liver tissue; while levels of ALB in serum and GSH in liver tissue were remarkably reduced in model group compared with normal group Compared with model group, 100 and 150 mg?kg-1?SWEs and bifendate notably decreased liver weight and index, levels of ALT, AST and TBIL in serum, NOS activity and MDA level in liver tissue in acute liver injury mice induced by CCl4?treatment; Meanwhile significantly increased levels of ALB in serum and GSH in liver tissue As a conclusion, SWEs has a significant protective effect on CCl4.induced liver injury mice, which might be related to the antioxidant function.

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Last Update: 2015-06-08