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Effects of Soy Isoflavones and Saponins on Hepatic Antioxidative Activity of Mice with Acute Liver Injury Induced by D galactoamine(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2014年01期
Page:
139-141
Research Field:
Publishing date:

Info

Title:
Effects of Soy Isoflavones and Saponins on Hepatic Antioxidative Activity of Mice with Acute Liver Injury Induced by D galactoamine
Author(s):
YIN Xuezhe 1 ; JIN Yanhua 1 ; WANG Yujiao 2 ; QUAN Jishu 2
1.Affiliated Hospital of Yanbian University,Yanji 133000,China;2.Medical College of Yanbian University,Yanji 133000,China
Keywords:
Soy; Isoflavones; Saponins; Liver injury; Antioxidative
PACS:
R285.5
DOI:
10.11861/j.issn.1000-9841.2014.01.0139
Abstract:
For the purpose of studying the protective effect of soy isoflavones and saponins on acute liver injury induced by D galactoamine(GalN)in mice,the experimental mice were randomly assigned to the normal control,model control,soy isoflavone,saponin and bifendate(positive control)groups.Animals were treated once daily for 7 days.GalN were given intraperitoneally to the mice of groups,and then the alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),lipid hydroperoxide(LOOH),malondialdehyde(MDA),reduced glutathione(GSH),superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)were detected by the colorimetric method.The administration with soy isoflavones and saponins reduced the serum ALT and AST activities,increased the serum ALB level,decreased the hepatic LOOH and MDA contents,and increased the SOD,CAT,GPx and GSH levels of liver in mice with acute liver injury.It is suggested that soy isoflavones and saponins have protective effects on acute liver injury induced by GalN in mice,probably via antioxidative activity.

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Last Update: 2014-08-04