Study on Anti-hyperuricemia Activity of Soybean Isoflavone(PDF)
《大豆科学》[ISSN:1000-9841/CN:23-1227/S]
- Issue:
- 2013年02期
- Page:
- 279-282
- Research Field:
- Publishing date:
Info
- Title:
- Study on Anti-hyperuricemia Activity of Soybean Isoflavone
- Author(s):
- CHEN Yu-sheng
- （School of Biochemical and Environmental Engineering，Nanjing Xiaozhuang University，Nanjing 211171，China）
- Keywords:
- Soybean isoflavone; Hyperuricemia; Potassium oxonate; Mice
- PACS:
- -
- DOI:
- 10.3969/j.issn.1000-9841.2013.02.032
- Abstract:
- The anti-hyperuricemia activity of soybean isoflavone in hyperuricemic mice induced by potassium oxonate was discussed.Kunming male mice were divided randomly into normal control group，and 5 hyperuricemic groups with model control，5 mg·kg-1 allopurinol and 25，50，100 mg·kg-1soybean isoflavone.Mice were orally administered once daily with 250 mg·kg-1 potassium oxonate for 7 continuous days to create the model.Three doses of soybean isoflavone were orally initiated on the day 1 h after potassium oxonate was given，separately.Serum uric acid，creatinine and urea nitrogon levels，as well as urinary uric acid and creatinine levels were measured.The results indicated that，compared with model group，soybean isoflavone significantly reduced serum uric acid，creatinine and urea nitrogon levels，increased 24 h uric acid and creatinine excretion，and fractional excretion of uric acid in hyperuricemic mice.In conclusion，the antihyperuricemia effect of soybean isoflavone was attributed to uric acid excretion enhancement.
Last Update: 2014-04-03