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Meta Analysis for Soybean isoflavones Intake and the Risk of Breast Cancer(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2012年05期
Page:
817-821
Research Field:
Publishing date:

Info

Title:
Meta Analysis for Soybean isoflavones Intake and the Risk of Breast Cancer
Author(s):
REN Guo-feng; YANG Jun-feng; WANG Meng; HUANG Yi-ming
School of Public Health,Central South University,Changsha 410078,Hunan,China
Keywords:
Soybean isoflavones; Breast cancer; Meta analysis
PACS:
R151.3
DOI:
10.3969/j.issn.1000-9841.2012.05.028
Abstract:
To study the association between soybean isoflavones intake and the risk of breast cancer by conducting Meta analysis.Using the key words,soybean isoflavones,soy,phytoestrogen,in combination with breast cancer,the databases of the Medline,Pubmed,Embase,CNKI and Wanfang from January 1996 to December 2011 were searched.The epidemiological studies met the inclusion criteria,and extracted data using a standardized form were selected.The cohort study and nested case-control study were included only.The analysis of combine RR/OR and homogeneity was performed using Review Manager.Meta-regression was conducted by Stata12.0,and the funnel plot and the Egger’s test were adopted to examine the potential publication bias.A total of sixteen studies met the inclusion criteria and were included,with the cases number of 6159.Compared the highest with the lowest intake,soybean isoflavones intake significantly reduced the breast cancer risk by 20% in post-menopausal women(pooled RR=0.80,95%CI:0.71-0.91;I2=34%,P=0.17),but it had no significance association in pre-menopausal women.The protective effect of soy isoflavones was observed only among studies conducted in Asian women(pooled RR=0.82,95%CI:0.70-0.96;I2=23%,P=0.26),but not in western women(pooled RR=0.98,95%CI:0.90-1.08;I2=33%,P=0.14).Results suggest soybean isoflavones intake could reduce the risk of breast cancer in post-menopausal women,especially for Asian women.

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Last Update: 2014-08-19