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Effect of Soybean Isoflavones and Saponins on Hepatic Oxidative Stress of Rats in Early Stage of Hepatocarcinogenesis(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2012年04期
Page:
675-677
Research Field:
Publishing date:

Info

Title:
Effect of Soybean Isoflavones and Saponins on Hepatic Oxidative Stress of Rats in Early Stage of Hepatocarcinogenesis
Author(s):
ZHAO Wen-xi; WANG Xia; JIN Ai-hua; QUAN Ji-shu
Medical College of Yanbian University,Yanji 133000,Jilin,China
Keywords:
Soybean; Isoflavones; Saponins; Hepatocarcinogenesis; Oxidative stress
PACS:
R154.4
DOI:
10.3969/j.issn.1000-9841.2012.04.032
Abstract:
The early stage of hepatocarcinogenesis was established by the method of Solt and Farber,and the rats were administered with 100 mg·kg-1 of soybean isoflavones and saponins for 42 days.At the end of experiment,the animals were killed and the liver homogenates and liver mitochondria were extracted.Then the activities of alanine trasaminase(ALT),aspartate aminotransferdse(AST),γ-glutamyl transpeptidase(γ-GT),glutathione S-transferase(GST),superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-PX),as well as the content of malondialdehyde(MDA)were detected by colorimetric method.The results showed that the administration with soybean isoflavones and saponins reduced the hepatic activities of ALT,AST,γ-GT and GST,increased the SOD,CAT and GSH-PX and decreased the MDA of liver and liver mitochondria of rats in early stage of hepatocarcinogenesis.It is suggested that soybean isoflavones and saponins could elevate hepatic injury and reduce hepatic oxidative stress of rats in early stage of hepatocarcinogenesis.This function will be helpful for the prevention of liver cancer.

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Last Update: 2014-08-19