Effects of Transgenic Soybean Feed on Proliferation of Spleen Lymphocyte in Male Mice(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:

2012年02期

Page:

291-294

Research Field:

Publishing date:

Info

Title:

Effects of Transgenic Soybean Feed on Proliferation of Spleen Lymphocyte in Male Mice

Author(s):

Chun-bin¹; ZHANG Wei¹; LIU Biao²

1.Institute of Reproductive Immunology,Jinan University,Guangzhou 510632,Guangdong;

2.Nanjing Institute of Environmental Science,Ministry of Environmental Protection,Nanjing 210042,Jiangsu,China

Keywords:

Transgenic glyphosate-resistant soybean; Feed; Male mice; MTT; Lymphocytes proliferation

PACS:

S816.7

DOI:

10.3969/j.issn.1000-9841.2012.02.028

Abstract:

In recent years,there have been a notable concerns on the safety of genetically modified(GM)foods,especially transgenic soybean.To evaluate effects of soybean on immunological function and possible genetic effects for progeny in male mice，male Kunming mice were fed with glyphosate feed for short-term of 30 and long-term of 90 days.Cell proliferation of spleen lymphocyte was analyzed with MTT assay.The sampling time was 0,2,7,14 and 30 day.For progeny test,male mice and female fed with transgenic soybean feed were mated and produced progeny F₁.There were no significant adverse effects on cell proliferation of spleen for parent mice at different time during 30 day feeding trial（P＞0.05）.It was also showed that cell proliferation of spleen was not affected for long-term of 90 days.For progeny,no adverse effect on cell proliferation of spleen was found both for 30 and 90 days.It was showed that there was no significant adverse effect on cell proliferation of spleen for parent and progeny male mice during 30 and 90 day feeding trial of transgenic soybean.There was no possible potential of genetic toxicology in male mice fed with transgenic soybean.

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