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Soybean Trypsin Inhibitor Shows Anti-obesity Effect in High Fat Diet-Induced Obesity Mice(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2012年02期
Page:
284-287
Research Field:
Publishing date:

Info

Title:
Soybean Trypsin Inhibitor Shows Anti-obesity Effect in High Fat Diet-Induced Obesity Mice
Author(s):
HUANG Gao-xia; ZHANG Li; WANG Dong-feng; SONG Yan-bin
College of Food Science & Engineering,Ocean University of China,Qingdao 266003,Shandong,China
Keywords:
Soybean trypsin inhibitor(SBTI); High fat diet; Obesity; Weight reducing
PACS:
TS201.4
DOI:
10.3969/j.issn.1000-9841.2012.02.026
Abstract:
One hundred and twenty weaning ICR mice were divided into 2 groups,normal mice(NM)and fat mice(FM)to establish high fat diet-induced obesity mice model.When the final weight of FM were higher than NM by 20%,NM and FM were regarded as obesity prevention and treatment group,respectively,and three dosages of SBTI were given by gavage for 42 d.At the end of the experiment,weight and triglyceride(TG),free fatty acid(FFA),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TCH)were deterrnine to investigate the anti-obesity effect of SBTI in obesity model.The result showed that compared with prevention control group,weight,TG,FFA of the obesity prevention group with high dosage SBTI significantly decreased,HDL-C of that group significantly increased.Compared with model control group,weight,TG,FFA of the obesity treatment group with high dosage SBTI significantly decreased,HDL-C of that group significantly increased.The differences of TCH were not significant in both groups.So it suggests that SBTI is effective for obesity prevention and treatment.

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Last Update: 2014-08-16