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Effect of Soybean Isoflavones and Saponins on Serum Marker Enzymes and Antioxidative Activities of Rat with Hepatic Preneoplasia(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2012年01期
Page:
124-126
Research Field:
Publishing date:

Info

Title:
Effect of Soybean Isoflavones and Saponins on Serum Marker Enzymes and Antioxidative Activities of Rat with Hepatic Preneoplasia
Author(s):
XU Hui-xian; WANG Xia; JIN Yan-hua; YIN Xue-zhe
Affiliated Hospital of Yanbian University，Yanji 133000，Jilin，China
Keywords:
Soybean; Isoflavones; Saponins; Hepatic; Preneoplastic lesions; Antioxdative
PACS:
R285.5
DOI:
10.3969/j.issn.1000-9841.2012.01.028
Abstract:
The hepatic preneoplastic lesions were induced by the modified protoco1 of Solt and Farber.Rats were administered with soybean isoflavones and saponins for 42 days，then the tumor necrosis factor-α(TNF-α)was determined with ELISA method.The activities of γ-glutamyl transpeptidase(γ-GT)，alanine trasaminase(ALT)，aspartate aminotransferdse(AST)，superoxide dismutase(SOD)，catalase(CAT)，glutathione peroxidase(GSH-PX)，as well as the contents of malondialdehyde(MDA)and nitric oxide(NO)were detected by the spectrometric method.Soybean isoflavones and saponins intake reduced the activities of serum γ-GT，ALT and AST，increased the serum SOD，CAT，GSH-PX activities，and decreased the serum MDA and NO levels in rats with hepatic preneoplastic lesions，however，no significant effect on serum TNF-α level was detected.It is suggested that soybean isoflavones and saponins exhibited an inhibitory effect on formation of hepatic preneoplastic lesions in rats，probably via its antioxdative activity.

References:

[1]Quan J S，Yin X Z，Kanazawa T.Effect of soybean hypocotyl extract on lipid peroxidation in GK rats[J].Journal of Clinical Biochemistry and Nutrition，2009，44(3):212-217.

[2]Ishii Y，Tanizawa H.Effects of soyasaponins on lipid peroxidation through the secretion of thyroid hormones[J].Biological Pharmaceutical Bulletin，2006，29:1759-1763.

[3]金梅花，许惠仙，金花，等.大豆异黄酮和皂甙对结肠癌细胞增殖和凋亡的研究[J].大豆科学，2008，27(6):1028-1031.（Jin M H，Xu H X，Jin H，et al.Effect of soybean isoflavones and saponins on proliferation and apoptosis of colon carcinoma cell HT-29[J].Soybean Science，2008，27(6):1028-1031.）

[4]全吉淑，尹学哲，工藤重光.大豆胚轴中大豆皂甙的提取及其对α-葡萄糖苷酶的抑制作用[J].食品研究与开发，2006，27(10):4-6.（Quan J S，Yin X Z，Kudou S.Isolation and purification of soyasaponins from soybean hypocotyl[J].Food Research and Development，2006，27(10):4-6.）

[5]Yin Z Z，Jin H L，Shen M H，et al.Inhibitory effect of Boschniakia rossica?on DEN induced precancerous hepatic foci and its antioxidative activities in rats[J].Chinese Journal of Cancer Research，1999;11:169-173.

[6]汪霞，周微，李天，等.草苁蓉环烯醚萜对肝癌前病变大鼠血清标志酶及抗氧化活性的影响[J].食品科技，2010，35(7):242-245.（Wang X，Zhou W，Li T，et al.Effect of iridoid glucosides from Boschniakia rossica?on serum marker enzymes and antioxidative activities of rat with hepatic preneoplasia[J].Food Science and Technology，2010，35(7):242-245.）

[7]李文惠，陈卫，李亢宗，等.肿瘤患者血GSH—PX活性变化的研究[J].肿瘤防治研究，1995，22(3):159，161.（Li W H，Chen W，Li K Z，et al.The research of blood GSH-PX activity in the patients with tumour[J].Cancer Research on Prevention and Treatment，1995，22(3):159，161.）

[8]丰平，刘树红，李霞，等.槲芪散对肝癌前病变大鼠肝脏线粒体结构的影响[J].中药药理与临床，2008，24(1):56-57.（Feng P，Liu S H，Li X，et al.Effects of Huqisan on chondriosome structure in hepatic precancerosis of rats[J].Pharmacology and Clinics of Chinese Materia Medica，2008，24(1):56-57.）

[9]Sagar S M，Singh G，Hodson D I，et al.Nitric oxide and anti-cancer therapy[J].Cancer Treatment Reviews，1995，21:159-181.

[10]肖顺汉，刘明华，钟琳，等.克癌新对荷瘤小鼠IL-2、IL-6、IL-12、TNF-α水平的影响[J].中药药理与临床，2008，24(2):82-86.（Xiao S H，Liu M H，Zhong L，et al.Effects of Keaixin on the level of IL-2，IL-6，IL-12 and TNF-αin tumor-bearing mice[J].Pharmacology and Clinics of Chinese Materia Medica，2008，24(2):82-86.）

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Last Update: 2014-08-15