Comparison of the Bioavailability of Soybean Selenoprotein and Sodium Selenite(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:

2010年03期

Page:

534-536

Research Field:

Publishing date:

Info

Title:

Comparison of the Bioavailability of Soybean Selenoprotein and Sodium Selenite

Author(s):

TIAN Jun-mei¹;  ZHANG Ding²;  FU Rui-juan¹;  ZHANG Rui¹;  HE Wei³

1.College of Public Health, Zhengzhou University, Zhengzhou 450001;

2.Henan Center for Disease Control and Prevention, Zhengzhou 450016;

3.Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou 450052, Henan, China

Keywords:

Low selenium; Soybean selenoprotein; Bioavailability; Glutathione peroxidase

PACS:

R151.2

DOI:

10.11861/j.issn.1000-9841.2010.03.0534

Abstract:

The objective of this study was to observe the bioavailability of the soybean selenoprotein with the sodium selenite as reference. Male SD rats were chosen as the experimental object to establish the low-selenium animal model. The rats were given soybean selenoprotein or sodium selenite by intragastric administration. Selenium content, glutathione peroxidase (GSH-Px) and thioredoxin reductase (TrxR) activities in blood, liver and kidney of the rats were determined to compare the bioavailability of the selenoprotein and the sodium selenite. Compared with control group, both the selenium contents and the activities of the selenoenzymes were enhanced significantly (P＜0.05). Much higher tissue selenium accumulation was caused in the sodium selenite group. The activities of the selenoenzymes in the soybean selenoprotein group were higher than that in the sodium selenite group. Results suggest that the soybean selenoprotein is high-efficiency and low-toxicity, and the effects of its absorption and utilization are superior to the sodium selenite.

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