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Anti Colon Tumor Effect of Soyasapogenols(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2009年01期
Page:
144-147
Research Field:
Publishing date:

Info

Title:
Anti Colon Tumor Effect of Soyasapogenols
Author(s):
QUAN Ji-shu; WANG Xia; XU Hui-xian; YIN Xue-zhe
Medical College of Yanbian University，Yanji 133000，Jilin，China
Keywords:
Soybean; Sapogenols; Colon cancer; Apoptosis
PACS:
R282.7
DOI:
10.11861/j.issn.1000-9841.2009.01.0144
Abstract:
Soyasaponins have been observed to limit many kind of tumor cell proliferation by inducing apoptosis.Soyasaponins were isolated from soybean hypocotyl with C18?reversed phase column chromatography，then soyasapogenols were prepared by hydrolysis of soyasaponins and their inhibitory effect on proliferation of colon carcinoma cell was investigated.MTT assay was used to examine the proliferation of HT-29 cell，TUNEL method was used for analysis of cell apoptosis.The results showed that soyasapogenols inhibited the proliferation and induced apoptosis of colon carcinoma cells in a time- and concentration-dependent manner in the concentration of 40-160 mgL-1.The inhibitory ratio of soyasapogenol A and B on cell proliferation was（48.7±1.3)% and（42.6±2.0)%，respectively；the apoptosis ratio on carcinoma cell was（37.0±1.2)% and (29.5±0.7)%，respectively.It is suggested that soyasapogenols could exert an anti-colon cancer effect via induction of apoptosis.

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Last Update: 2014-10-03