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Preparation and in Vitro Dissolution of Soybean Isoflavone Colon Targeting Sustained-Release Pellet Capsules(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2008年05期
Page:
895-897
Research Field:
Publishing date:

Info

Title:
Preparation and in Vitro Dissolution of Soybean Isoflavone Colon Targeting Sustained-Release Pellet Capsules
Author(s):
REN Yan-rong1; 2; LI Xiao-bo2; CHEN Xiao-lin2
1 College of Bioengineering，Chongqing University，Chongqing 400044；
2Chongqing Education College，Chongqing 400067，China
Keywords:
Colon targeting; Soybean isoflavone; Sustained-release pellet capsules; In vitro dissolution
PACS:
Q977.9
DOI:
10.11861/j.issn.1000-9841.2008.05.0895
Abstract:
To study the formulation and processing of soybean isoflavone colon targeting sustained-release pellet capsules，and to evaluate its release behavior in vitro.The pellets were prepared by extrusion/spheronization.Orthogonal design was used to screen the formulation of soybean isoflavone sustained-release pellet capsules and to optimize the manufacturing process.The optimized formulation of soybean isoflavone sustained-release pellet capsules and processing followed as:5 g of soybean isoflavone，6 g of HPMC(Hydroxypropyl Methyl Cellulose),7 g of EC(Ethyl Cellulose),6 g of MCC(Microcrystalline Cellulose)，the time of spheronization was 20 min，and 50 % alcohol as adhesive.The prepared pellets had good spheronization，the critical angle of plan was 12.4 and the recovery was 93.8 %.Moreover，in vitro release of soybean isoflavone sustained-release pellet capsules properly described by first-order kinetics and the sustained-release of the pellets was evident.The colon targeting sustained-release soybean isoflavone pellets capsules with in vitro sustained release characteristics were successfully prepared.

References:

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Last Update: 2014-10-06