|Table of Contents|

Preparation and Property of Peg-coated Vitamin C-containing Liposome(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2008年03期
Page:
505-508
Research Field:
Publishing date:

Info

Title:
Preparation and Property of Peg-coated Vitamin C-containing Liposome
Author(s):
CHEN Ting-ting; CAO Guang-qun; YANG Chen
School of Chemical and Material Engineering，Jiangnan University，Wuxi 214122，Jiangsu，China
Keywords:
Vitamin C; Liposome; Polyethylene glycol(PEG)
PACS:
TQ658
DOI:
10.11861/j.issn.1000-9841.2008.03.0505
Abstract:
The purpose of this work was to improve the stability of liposome by coating PEG.The vitamin C-containing liposome，which had been prepared by film dispersion-ultrasonic emulsify method，was coated with PEG by simply mixing the liposomal suspension with the PEG solution.The structure determined by electron microscope confirmed the existence of polymer layer on the surface of liposome particles.By comparison with the non-coated liposome，the polymer coated one had larger particle size and better encapsulation.The changes of A500nmand the malondialdehyde(MDA) content in liposome in different temperature were investigated，the optimal storage condition was light-avoiding at 4 ℃，and the polymer coated one showed less increase in A500nmand MDA.Results suggest that the vitamin C-containing liposome could be effectively coated by PEG and its stability was improved.

References:

[1] Kristl J，Volk B，Gaǎperlin M，et al.Effect of colloidal carriers on ascorbyl palmitate stability[J].European Journal of Pharmaceutical Sciences，2003，19：181-189.

[2]Woodle M C，Lasic D D.Sterically stabilized liposome[J].Biochimica et Biophysica Acta，1992，1113：171-199.
[3]Zanin M H A，Torriani I C L，Zollner R L，et al.Physical characterization of surface-modified liposomes by incorporation of gangliosides designed for immunotherapies[J].Colloids and Surfaces A： Physicochem.Eng.Aspects，2004，251：175-182.
[4]Tirosh O，Barenholz Y，Katzhendler J，et al.Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer[J].Chemistry and Physics of Lipids，2005，135： 117-129.
[5]刘亚文，曹光群，陈婷婷.维生素C脂质体的制备研究[J].大豆科学，2007，26(2)：270-272.(Liu Y W，Cao G Q，Chen T T.Study on preparation of vitamin C liposome[J].Soybean Science，2007，26(2)：270-272.)
[6]Takeuchi H，Yamamoto H，Toyoda T，et al.Physical stability of size controlled small unimaller liposome coated with a modified polyvinyl alcohol[J].International Journal of Pharmaceutics，1998，164：103-111.
[7]王岩，周莉玲.青藤碱脂质体的制备及稳定性研究[J].中成药，2005，27(2)：757-760.(Wang Y，Zhou L L.Study on preparation and stability of sinomenine liposomes[J].Chinese Traditional Patent Medicine，2005，27(2)：757-760.)
[8]张灵芝.脂质体制备及其在生物医学中的应用[M].北京：北京医科大学，中国协和医科大学联合出版社，1998：57-58.(Zhang L Z.Preparation of liposome and its application in biomedicine[M].Beijing：Peking University Health Science Center，Peking Union Medical College Press，1998：57-58.)
[9]朱斌，许时婴，夏书芹.薄膜水化法制备辅酶Q10脂质体[J].食品与机械，2006，22(6)：39-41.(Zhu B，Xu S Y，Xia S Q.Preparation of coenzyme Q10liposomes by thin-film rehydration method[J].Food & Machinery，2006，22(6)：39-41.)
[10]孙京新，周光宏，徐幸莲.猪肉微粒体脂肪酸氧化产物对氧合肌红蛋白氧化的影响[J].南京农业大学学报，2004，27(1)：101-104.(Sun J X，Zhou G H，Xu X L.Effect of oxidation products of fatty acids in microsomes from pork on oxymyoglobin oxidation in vitro[J].Journal of Nanjing Agricultural University，2004，27(1)：101-104.)
[11]陈涛，王昭，傅经国，等.聚乙二醇修饰脂质体研究[J].世界最新医学信息文摘，2003，2(5)：801-805.(Chen T，Wang Z，Fu J G，et al.Research of modifying liposome with polyethylene glycol[J].Digest of The World Latest Medical Information，2003，2(5)：801-805.)

Memo

Memo:
-
Last Update: 2014-10-08