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Inhibition of Soybean Isoflavones and Saponins on Oxidation of Lipoproteins in Diabetic Rats(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2008年01期
Page:
170-172
Research Field:
Publishing date:

Info

Title:
Inhibition of Soybean Isoflavones and Saponins on Oxidation of Lipoproteins in Diabetic Rats
Author(s):
YIN Xue-zheXU Hui-xianand JIN Hua
Medical College of Yanbian University,Yanji 133000,Jilin,China
Keywords:
SoybeanIsoflavoneSaponinLipid peroxideOxidative susceptibilityLipoprotein
PACS:
-
DOI:
10.11861/j.issn.1000-9841.2008.01.0170
Abstract:
There is increasing evidence that lipid peroxidation and oxidative modification of low density lipoprotein (LDL) is important in atherogenesis.Soybean isoflavones and saponins have many pharmacological effects.In this study we investigated the effect of soybean isoflavones and saponins on lipid peroxide(LPO) levels of plasma and lipoproteins in GK diabetic rats,and its efficacy on the reduction of susceptibility of LDL to oxidation.Soybean isoflavones and saponins were extracted from soybean hypocotyl,and detected with high-performance liquid chromatography (HPLC).Diabetic rats were given feed containing 100 g kg-1soybean isoflavones and saponins for 20 weeks,and lipid peroxide (LPO) levels of lipoproteins and susceptibilities of lipoproteins to oxidation were then investigated.The results showed that LPO levels of blood,LDL and HDL in diabetic rats were significantly decreased after soybean isoflavone and saponin intake;lag phage of LDL oxidation curve in vitro was prolonged noticeably.It is suggested that soybean isoflavones and saponins,which can decrease the peroxidizability of lipoproteins and promote resistance to LDL oxidation,minght be useful in prevention and treatment of diabetes mellitus and diabetes-associated diseases.

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Last Update: 2014-10-10