|Table of Contents|

Structure Analysis of Genistein and Daidzein(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:
2008年01期
Page:
128-133
Research Field:
Publishing date:

Info

Title:
Structure Analysis of Genistein and Daidzein
Author(s):
WEN Rui-zhi1LI Shui-fang1and ZENG Dong2
1 Central South University of Forestry & Technology,Changsha 410004,Hunan;
2 Hunan Center of Disease Control and Prevention,Changsha 410005,Hunan,China
Keywords:
GenisteinDaidzeinMass spectrumInfrared spectrumNuclear magnetic resonance spectrumTwo-dimension NMR spectrumStructure analysis
PACS:
-
DOI:
10.11861/j.issn.1000-9841.2008.01.0128
Abstract:
Genistein and daidzain are two primary soybean isoflavones,which have important biological activities.There are few reports about their structure analysis at the same time.The molecular structures of genistein and daidzain were analyzed at the same time by mass spectrum,infrared spectrum,1H-nuclear magnetic resonance(NMR) spectrum,13C-NMR spectrum and Two-dimension-NMR spectrum,which offers a useful method for the fingerprint analysis of mixture.To make sure the truth of mixture structure analysis,the article analyzed the molecular structures of genistein and daidzain from the aspect of molecular weight,primary function group and material structure.The method makes sure of the correctness of mixtures’structures and avoides separating mixtures before analyzed.The method is proved to be easy and fast.

References:

[1]Axelson M,Sjovall J,Gustafsson B E,and Setchell K D.1984.Soya-A dietary source of the non-steroidal oestrogen equol in man and animals.Journal of Endocrinology,102:49-56

[2]Cai Q, and Wei H.1996.Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice.Nutrition and Cancer,25(1):1-7[3]Fukutake M,Takahashi M,Ishida K,Kawamura H,Sugimura T,and Wakabayashi K.1996.Quantification of genistein and genistin in soybeans and soybean products.Food and Chemical Toxicology,34(5):457-461
[4]Gyorgy P,Murata K,and Ikehata H.1964.Antioxidants isolated from fermented soybeans (tempheh).Nature,203:870-872
[5]Herman C,Adlercreutz T,Goldin B R,Gorbach S L,Hockerstedt K A V,Watanabe S,Hamalainen E K,Markkanen M H,Makela T H,Wahala K T,Hase T A,and Fotsis T.1995.Soybean phytoestrogen intake and cancer risk.The Journal of Nutrition,125:757-770
[6]Jing Y,Nakaya K,and Han R.1993.Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo.Anticancer Research,13(4):1049-1054
[7]Matsukawa Y,Marui N,Sakai T,Satomi Y,Yoshida M,Matsumoto K,Nishino H,and Aoike A.1993.Genistein arrests cell cycle progression at G2-M.Cancer Research,53(6):1328-1331
[8]Murkies A L,Lombard C, Strauss B J, Wilcox G,Burger H G,and Morton M S.1995.Dietary flour supplementation decreases post-menopausal hot flushes:effect of soy and wheat.Maturitas,21(3):189-195
[9]PetersonC,and Barnes S.1991.Genistein inhibition of the growth of human breast cancer cells:Independence from estrogen receptors and the multi-drug resistance gene.Biochemical and Biophysical Research Communications.179(1):661-667
[10]Raines E W,and Ross R.1995.Biology of atherosclerotic plaque formation:possible role of growth factors in lesion development and the potential impact of soy.The Journal of Nutrition,125:624-630
[11]Setchell K D,Borriello S P,Hulme P,Kirk D N,and Axelson M.1984.Nonsteroidal estrogens of dietary origin:possible roles in hormone-dependent disease.American Journal of Clinical Nutrition,40:569-578
[12]Wang H, and Murphy P A.1994.Isoflavone content in commercial soybean foods.Journal of Agriculture and Food Chemistry,42(8):1666-1673
[13]Wei H,Bowen R,Cai Q,Barnes S,and Wang Y.1995.Antioxidant and antipromotional effects of the soybean isoflavone genistein.Proceedings of the Society for Experimental Biology and Medicine,208(1):124-13
[14]Wei H,Cai Q,and Rahn R O.1996.Inhibition of UV light and fenton reaction induced oxidative DNA damage by the soybean isoflavone genistein.Carcinogenesis,17(1):73-77
[15]Yanagihara K, Ito A,Toge T,and Numoto M.1993.Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract.Cancer Research,53(23):5815-5821
[16]Yu D Q,Yang J S,and Xie J X eds.1985.Analytical chemistry manual,the fifth Fascicule.Chemical Industry Press,China,Beijing,pp.742-743(于德泉,杨峻山,谢晶曦,著.1985.分析化学手册,第五分册.化学工业出版社,中国,北京,pp.742-743)

Memo

Memo:
-
Last Update: 2014-10-09