PREPARATION OF LIPOSOME MADE OF SOYBEAN LECITHIN(PDF)

《大豆科学》[ISSN:1000-9841/CN:23-1227/S]

Issue:

2007年03期

Page:

386-390

Research Field:

Publishing date:

Info

Title:

PREPARATION OF LIPOSOME MADE OF SOYBEAN LECITHIN

Author(s):

MU Xiao-mei¹; ZHONG Zhen-sheng²

1.Department of Chemistry & Chemical Engineering,Zhongkai University of Agriculture and Technology,Guangzhou 510225;

2.College of Chemistry,South China Univ of Tech,Guangzhou,510641

Keywords:

Liposome; Soybean lecithin; Entrapping efficienc; Leakage rate

PACS:

TQ645.9+6

DOI:

10.3969/j.issn.1000-9841.2007.03.021

Abstract:

The liposomes made with three kinds of soybean lecithin composed of phosphatidylcholine( PC)，phosphatidyletthanolamine (PE)，phosphatidylinositol ( PI) and phosphatidic( PA) was prepared by using reverse phrase evaporation method.The effect of the soybean lecithin composition on the physiochemical properties by investigating diameter,zeta potential，entrapping efficiency,leakage rate and stability .The Transmission electron micrographs showed that all the liposomes were spherical-shape.The liposome made of Lecithin SPC-3 which contains 93.62％PC showed large diameter, higher entrapping efficiency and lower leakage rate than that of lecithin SPC-1 and Lecithin SPC-2 which contain 31.29％and 58.19％ PC separately.The liposome made of lecithin SPC-1 was more stable than that of lecithin SPC-2 and lecithin SPC-3 due to the smallest zeta potential of Lecithin SPC-1

References:

［1］张灵芝.脂质体制备及其在生物医学中的应用［M］.北京：北京医科大学、北京协和医科大学联合出版社，1998：1-53.

Memo

Memo:

-

Common functions